Document Detail


Beneficial effect of anisodamine in hemorrhagic shock.
MedLine Citation:
PMID:  6728045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anisodamine , an alkaloid extracted from Anisodus tanguticus , is widely used in China in the treatment of septic shock, but its mechanism of action is unknown. We studied its antishock action in cats in a well controlled model of hemorrhagic shock. A bolus dose of 1 mg/kg was given intravenously 20 min after MABP was stabilized at 40-45 mm Hg, followed by i.v. infusion of 2 mg/kg/h during the oligemic period. Two hours post-reinfusion, MABP was significantly higher (106 +/- 10 mm Hg) in the drug-treated group than in shock cats receiving only vehicle (53 +/- 6 mm Hg, P less than 0.001). Anisodamine treated shock cats exhibited significantly lower cathepsin D activity (P less than 0.02) and amino-nitrogen concentration (P less than 0.001) than untreated shock animals. Plasma myocardial depressant factor (MDF) activity was significantly increased in the untreated shock cats (61 +/- 6 Units/ml), but the plasma accumulation of MDF was significantly blunted by anisodamine (32 +/- 5 Units/ml, P less than 0.01). Anisodamine did not increase superior mesenteric artery flow ( SMAF ) in this model of hemorrhagic shock as there was no significant difference in SMAF between the two shocked groups. Thus, the beneficial effect of anisodamine probably is not due to vasodilation of the splanchnic vasculature. In vitro analysis indicates that the drug has a direct anti-proteolytic action in cat pancreatic homogenates. This may partly explain the mechanism of its action, which appears to be complex.
Authors:
J Su; C E Hock; A M Lefer
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  325     ISSN:  0028-1298     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  1984 Apr 
Date Detail:
Created Date:  1984-07-18     Completed Date:  1984-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  360-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Cathepsin D
Cathepsins / blood*
Cats
Disease Models, Animal
Infusions, Parenteral
Male
Mesenteric Arteries / physiology
Myocardial Depressant Factor / blood*
Pancreas / metabolism
Peptides / blood*
Regional Blood Flow / drug effects
Shock, Hemorrhagic / blood,  drug therapy*,  physiopathology
Solanaceous Alkaloids / pharmacology,  therapeutic use*
Vasodilator Agents / pharmacology,  therapeutic use*
Chemical
Reg. No./Substance:
0/Myocardial Depressant Factor; 0/Peptides; 0/Solanaceous Alkaloids; 0/Vasodilator Agents; 55869-99-3/anisodamine; EC 3.4.-/Cathepsins; EC 3.4.23.5/Cathepsin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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