| Beneficial effect of amrinone on the size of acute regional ischemia in isolated rabbit hearts. | |
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MedLine Citation:
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PMID: 8268439 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of inotropes on myocardial ischemia is difficult to predict because they may influence the determinants of myocardial O2 demand and O2 supply differently. Several PDE-inhibitors have been reported to possess antiischemic properties related to their hemodynamic and O2-sparing effects. To assess whether PDE-inhibitors also possess direct cardioprotective properties, the effects of amrinone (2.5 x 10(-5) mol/L) in comparison to isoproterenol (5 x 10(-9) mol/L) and ouabain (1.5 x 10(-7) mol/L) were studied in isolated rabbit hearts perfused according to Langendorff at a constant pressure (70 cmH2O) and electrically driven at a constant pacing rate. Regional ischemia was induced by coronary artery ligation and quantified by epicardial NADH fluorescence. All substances significantly increased the actively developed left ventricular pressure to a similar extent (+20%) (P < 0.05). Coronary flow was significantly decreased by ouabain (-15%) and significantly increased by isoproterenol (+25%) and particularly by amrinone (+50%) (P < 0.05). Neither ouabain nor isoproterenol significantly changed the intensity or the distribution pattern of NADH fluorescence, whereas the size of the ischemic zone was significantly reduced by amrinone (-25%) (P < 0.05). The PDE-inhibitor amrinone was shown to possess a direct cardioprotective effect by improving myocardial perfusion and O2 supply in isolated rabbit hearts. |
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Authors:
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A F Rump; R Rösen; B Sigmund; J Fuchs; S Dhein; W Klaus |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Journal of cardiothoracic and vascular anesthesia Volume: 7 ISSN: 1053-0770 ISO Abbreviation: J. Cardiothorac. Vasc. Anesth. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-01-31 Completed Date: 1994-01-31 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9110208 Medline TA: J Cardiothorac Vasc Anesth Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 573-8 Citation Subset: IM |
Affiliation:
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Institut für Pharmakologie, Universität Köln, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amrinone
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therapeutic use* Animals Blood Pressure / drug effects Coronary Circulation / drug effects Fluorescence Histocytochemistry Isoproterenol / therapeutic use Male Myocardial Contraction / drug effects Myocardial Ischemia / drug therapy*, metabolism, pathology* Myocardium / metabolism, pathology NAD / metabolism Ouabain / therapeutic use Rabbits Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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53-84-9/NAD; 60719-84-8/Amrinone; 630-60-4/Ouabain; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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