Document Detail

Beneficial effect of amrinone on the size of acute regional ischemia in isolated rabbit hearts.
MedLine Citation:
PMID:  8268439     Owner:  NLM     Status:  MEDLINE    
The effect of inotropes on myocardial ischemia is difficult to predict because they may influence the determinants of myocardial O2 demand and O2 supply differently. Several PDE-inhibitors have been reported to possess antiischemic properties related to their hemodynamic and O2-sparing effects. To assess whether PDE-inhibitors also possess direct cardioprotective properties, the effects of amrinone (2.5 x 10(-5) mol/L) in comparison to isoproterenol (5 x 10(-9) mol/L) and ouabain (1.5 x 10(-7) mol/L) were studied in isolated rabbit hearts perfused according to Langendorff at a constant pressure (70 cmH2O) and electrically driven at a constant pacing rate. Regional ischemia was induced by coronary artery ligation and quantified by epicardial NADH fluorescence. All substances significantly increased the actively developed left ventricular pressure to a similar extent (+20%) (P < 0.05). Coronary flow was significantly decreased by ouabain (-15%) and significantly increased by isoproterenol (+25%) and particularly by amrinone (+50%) (P < 0.05). Neither ouabain nor isoproterenol significantly changed the intensity or the distribution pattern of NADH fluorescence, whereas the size of the ischemic zone was significantly reduced by amrinone (-25%) (P < 0.05). The PDE-inhibitor amrinone was shown to possess a direct cardioprotective effect by improving myocardial perfusion and O2 supply in isolated rabbit hearts.
A F Rump; R Rösen; B Sigmund; J Fuchs; S Dhein; W Klaus
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  7     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  1993 Oct 
Date Detail:
Created Date:  1994-01-31     Completed Date:  1994-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  573-8     Citation Subset:  IM    
Institut für Pharmakologie, Universität Köln, Germany.
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MeSH Terms
Amrinone / therapeutic use*
Blood Pressure / drug effects
Coronary Circulation / drug effects
Isoproterenol / therapeutic use
Myocardial Contraction / drug effects
Myocardial Ischemia / drug therapy*,  metabolism,  pathology*
Myocardium / metabolism,  pathology
NAD / metabolism
Ouabain / therapeutic use
Ventricular Function, Left / drug effects
Reg. No./Substance:
53-84-9/NAD; 60719-84-8/Amrinone; 630-60-4/Ouabain; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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