Document Detail


Beneficial and detrimental effects of glycemic control on cardiovascular disease in type 2 diabetes.
MedLine Citation:
PMID:  23314689     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Epidemiological data demonstrates that improved regulation of blood glucose correlates with better cardiovascular (CV) outcomes. Conversely, some interventional studies have demonstrated that tight glycemic control has no benefit or can even result in worse CV outcomes. These conclusions parallel the paradox that glycemic control has proven beneficial for microvascular outcomes, while few studies have demonstrated significant macrovascular benefits. This imprecise understanding conveys the need to better comprehend the mechanisms of glycemic control and its impact on CV disease. Such variations in data also require a more comprehensive approach to diabetes and CV disease in which multiple biomarkers such as low density lipoprotein (LDL), low adiponectin, elevated C-reactive protein (CRP) and well established clinical parameters such as high blood pressure, weight, and functional status are incorporated into clinical decision making. Reliance on one parameter in isolation such as glycemic control and one biomarker such as HbA1C does not provide an accurate assessment of CV outcomes.
Authors:
Pam R Taub; Erin Higginbotham; Robert R Henry
Related Documents :
23539399 - Type 1 diabetes mellitus with dual autoimmune mechanism related to pegylated interferon...
23996669 - A history of insulin coma therapy in australia.
4025449 - The effect of oral ritodrine therapy on glucose tolerance in pregnancy.
23519039 - Predictors of diabetes self-management in older adults receiving chemotherapy.
23069839 - Diabetes genetic predisposition score and cardiovascular complications among patients w...
15008839 - Coverage in screening for diabetic retinopathy according to screening provision: result...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Current cardiology reports     Volume:  15     ISSN:  1534-3170     ISO Abbreviation:  Curr Cardiol Rep     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888969     Medline TA:  Curr Cardiol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332     Citation Subset:  IM    
Affiliation:
University of California, San Diego, San Diego, CA, USA, ptaub@ucsd.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impact of managed care health insurance system for indigent patients with rheumatoid arthritis in Pu...
Next Document:  Hypoxia alters the epigenetic profile in cultured human placental trophoblasts.