Document Detail


Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates.
MedLine Citation:
PMID:  24563374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resveratrol has been proposed as a potential therapeutic to improve metabolic health during pregnancy, yet little is known about the fetal effects of this maternal dietary supplement. We hypothesized that when administered to pregnant nonhuman primates (NHPs), resveratrol would increase uterine blood flow and mitigate the harmful consequences of maternal Western-style diet (WSD) consumption. NHPs were fed a WSD (36% fat) supplemented with 0.37% resveratrol throughout pregnancy. Outcomes were compared with cohorts fed WSD alone and control chow (14% fat) to distinguish between WSD and resveratrol-specific effects in these animals. In the early third trimester, uterine blood flow was measured by Doppler ultrasound before fetal delivery and tissue collection. Resveratrol resulted in 30% maternal weight loss and improved glucose tolerance, increased uterine artery volume blood flow, and decreased placental inflammation and liver triglyceride deposition. In addition, fetal pancreatic mass was enlarged by 42%, with a 12-fold increase in proliferation by Ki67 immunohistochemistry. These results demonstrate that resveratrol use during pregnancy yields improvements in maternal and placental phenotype with beneficial effects in the fetal liver but an unexplained and concerning alteration in fetal pancreatic development, which strongly cautions against the use of resveratrol by pregnant women.
Authors:
Victoria H J Roberts; Lynley D Pound; Stephanie R Thorn; Melanie B Gillingham; Kent L Thornburg; Jacob E Friedman; Antonio E Frias; Kevin L Grove
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2014-02-21
Journal Detail:
Title:  FASEB journal : official publication of the Federation of American Societies for Experimental Biology     Volume:  28     ISSN:  1530-6860     ISO Abbreviation:  FASEB J.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-07-29     Completed Date:  2014-10-06     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  8804484     Medline TA:  FASEB J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2466-77     Citation Subset:  IM    
Copyright Information:
© FASEB.
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MeSH Terms
Descriptor/Qualifier:
Animals
Diet / adverse effects
Dietary Supplements / adverse effects
Female
Fetal Development / drug effects*
Fetus
Liver / drug effects,  embryology
Macaca
Pancreas / drug effects,  embryology
Placental Circulation / drug effects
Pregnancy
Regional Blood Flow / drug effects
Stilbenes / adverse effects*,  blood,  contraindications,  pharmacology*
Triglycerides / blood
Uterus / blood supply
Grant Support
ID/Acronym/Agency:
K01 DK090199/DK/NIDDK NIH HHS; K01-DK-090199/DK/NIDDK NIH HHS; P30 DK048520/DK/NIDDK NIH HHS; P51 OD011092/OD/NIH HHS; P51-OD-011092/OD/NIH HHS; R01 DK079194/DK/NIDDK NIH HHS; R24 DK090964/DK/NIDDK NIH HHS; R24-DK-090964/DK/NIDDK NIH HHS; S10 RR024585/RR/NCRR NIH HHS; S10-RR-024585/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Stilbenes; 0/Triglycerides; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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