Document Detail

Beneficial actions of a free radical scavenger in traumatic shock and myocardial ischemia.
MedLine Citation:
PMID:  7249259     Owner:  NLM     Status:  MEDLINE    
The role of prostanoids in shock states is complex because beneficial as well as deleterious prostanoids are formed during circulatory shock. Recent attention has focused on free radicals formed in the arachidonic acid cascade. MK-447, a free radical scavenger, at 1-4 mg/kg, was found to prolong survival in traumatic shock and to prevent the plasma appearance of a myocardial depressant factor (MDF) in shock rats. In the isolated cat heart perfused under ischemic conditions (ie, coronary flow less than 0.7 ml/min for 2 hours), MK-447 partially restored contractile performance after reestablishment of normal flow and partially prevented cardiac edema. In combination with the cyclooxygenase inhibitor, meclofenamate, MK-447 dramatically restored mechanical performance, prevented leakage of myocardial creatine kinase activity, and cardiac edema. It appears that MK-447 protects in traumatic shock and in myocardial ischemia by a mechanism related to removal of free radicals formed in arachidonic acid metabolism.
A M Lefer; H Araki; S Okamatsu
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulatory shock     Volume:  8     ISSN:  0092-6213     ISO Abbreviation:  Circ. Shock     Publication Date:  1981  
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414112     Medline TA:  Circ Shock     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  273-82     Citation Subset:  IM    
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MeSH Terms
Arachidonic Acids / metabolism
Butylated Hydroxytoluene / analogs & derivatives*,  pharmacology
Coronary Disease / metabolism*
Creatine Kinase / analysis
Free Radicals
Lysosomes / drug effects
Meclofenamic Acid / pharmacology
Myocardial Contraction / drug effects
Prostaglandin Endoperoxides / biosynthesis
Protease Inhibitors / pharmacology
Shock, Traumatic / drug therapy,  metabolism*
Reg. No./Substance:
0/Arachidonic Acids; 0/Free Radicals; 0/Prostaglandin Endoperoxides; 0/Protease Inhibitors; 128-37-0/Butylated Hydroxytoluene; 58456-91-0/2-aminomethyl-4-t-butyl-6-iodophenol; 644-62-2/Meclofenamic Acid; EC Kinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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