| The Beneficial Role of Vitamin D in Alzheimer's Disease. | |
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MedLine Citation:
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PMID: 22202127 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Alzheimer's disease (AD) is the most common form of dementia in the elderly individuals and is associated with progressive neurodegeneration of the human neocortex. Patients with AD have a high prevalence of vitamin D deficiency, which is also associated with low mood and impaired cognitive performance in older people. Genetic studies have provided the opportunity to determine which proteins link vitamin D to AD pathology (ie, the major histocompatibility complex class II molecules, vitamin D receptor, renin-angiotensin system, apolipoprotein E, liver X receptor, Sp1 promoter gene, and the poly(ADP-ribose) polymerase-1gene). Vitamin D also exerts its effect on AD through nongenomic factors, that is, L-type voltage-sensitive calcium channels, nerve growth factor, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide synthase. In conclusion, vitamin D clearly has a beneficial role in AD and improves cognitive function in some patients with AD. Calcitriol, 1αα,25-dihydroxyvitamin D(3), is best used for AD because of its active form of vitamin D(3) metabolite and its receptor in the central nervous system. |
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Authors:
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Khanh Vinh Qu 244 C Lu'o'ng; Lan Thi Ho 225 Ng Nguyên |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-27 |
Journal Detail:
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Title: American journal of Alzheimer's disease and other dementias Volume: - ISSN: 1938-2731 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101082834 Medline TA: Am J Alzheimers Dis Other Demen Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Vietnamese American Medical Research Foundation, Westminster, CA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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