| Beneficial effects of growth hormone-releasing peptide on myocardial oxidative stress and left ventricular dysfunction in dilated cardiomyopathic hamsters. | |
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MedLine Citation:
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PMID: 19942785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Growth hormone-releasing peptide (GHRP) may act directly on the myocardium and improve left ventricular (LV) function, suggesting a potential new approach to the treatment of cardiomyopathic hearts. The present study tested the hypothesis that the beneficial cardiac effects of GHRP might include attenuation of myocardial oxidative stress. METHODS AND RESULTS: Dilated cardiomyopathic TO-2 hamsters were injected with GHRP-2 (1 mg/kg) or saline from 6 to 12 weeks of age. F1B hamsters served as controls. Untreated TO-2 hamsters progressively developed LV dilation, wall thinning, and systolic dysfunction between 6 and 12 weeks of age. Marked myocardial fibrosis was apparent in untreated hamsters at 12 weeks of age in comparison with F1B controls. The ratio of reduced to oxidized glutathione (GSH/GSSG) was decreased and the concentration of 4-hydroxynonenal (4-HNE) was increased in the hearts of untreated TO-2 hamsters. Treatment with GHRP-2 attenuated the progression of LV remodeling and dysfunction, as well as myocardial fibrosis, in TO-2 hamsters. GHRP-2 also inhibited both the decrease in the GSH/GSSG ratio and the increase in the concentration of 4-HNE in the hearts of TO-2 hamsters. CONCLUSIONS: GHRP-2 can suppress the increase in the level of myocardial oxidative stress, leading to attenuation of progressive LV remodeling and dysfunction in dilated cardiomyopathic hamsters. (Circ J 2010; 74: 163 - 170). |
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Authors:
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Yosuke Kato; Mitsunori Iwase; Sahoko Ichihara; Hiroaki Kanazawa; Katsunori Hashimoto; Akiko Noda; Kohzo Nagata; Yasuo Koike; Mitsuhiro Yokota |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-27 |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 74 ISSN: 1347-4820 ISO Abbreviation: Circ. J. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-25 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 163-70 Citation Subset: IM |
Affiliation:
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Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University, Nagoya, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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metabolism Animals Cardiomyopathy, Dilated / genetics, metabolism* Cricetinae Disease Models, Animal Glutathione / metabolism Glutathione Disulfide / metabolism Glutathione Peroxidase / metabolism Male Mesocricetus Mutation Myocardium / metabolism* Oligopeptides / pharmacology* Oxidative Stress / drug effects* Sarcoglycans / genetics Superoxide Dismutase / metabolism Ventricular Dysfunction, Left / metabolism* Ventricular Remodeling / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Oligopeptides; 0/Sarcoglycans; 0/growth hormone-releasing peptide-2; 27025-41-8/Glutathione Disulfide; 29343-52-0/4-hydroxy-2-nonenal; 70-18-8/Glutathione; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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