Document Detail


Beneficial effects of adaptive servo ventilation in patients with chronic heart failure.
MedLine Citation:
PMID:  20679736     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Sleep-disordered breathing (SDB) is thought to be a state of inflammation caused by hypoxic stress. Whether adaptive servo ventilation (ASV) attenuates the inflammatory response and improves the cardiac function of patients with congestive heart failure (CHF) accompanied by SDB was not been investigated.
METHODS AND RESULTS: Seventeen inpatients with New York Heart Association (NYHA) II or III underwent polysomnography. There was a positive correlation between the apnea hypopnea index and high-sensitivity C-reactive protein (hs-CRP) level (r=0.753, P=0.016). The patients were divided into ASV (n=10) and non-ASV groups (n=7), and CHF-parameters were measured before and after ASV treatment. Improvement was noted for the NYHA class in the ASV group but not in the non-ASV group. In contrast to the non-ASV group, the level of brain natriuretic peptide (BNP), ejection fraction, and hs-CRP levels in the ASV group significantly improved (BNP, 212.1 ± 181.2 to 77.3 ± 54.0 pg/ml [P<0.05]; ejection fraction, 43.5 ± 6.4 to 53.3 ± 6.1% [P=0.002]; hs-CRP, 0.85 ± 0.58 to 0.21 ± 0.19 mg/dl, [P=0.008]). The increase in ejection fraction was correlated with a decrease in the hs-CRP level (r=-0.753, P=0.001).
CONCLUSIONS: Anti-inflammatory effects of ASV are important contributors for improving cardiac function in patients with CHF accompanied by SDB. 
Authors:
Takashi Koyama; Hiroyuki Watanabe; Yusuke Kobukai; Shin Makabe; Yoshiko Munehisa; Kenji Iino; Toshimitsu Kosaka; Hiroshi Ito
Related Documents :
21530296 - Clinical features of lung cancer in smokers with light and mild chronic obstructive pul...
21211006 - Small airway remodeling in acute respiratory distress syndrome: a study in autopsy lung...
13662856 - Cardiac operations with extracorporeal circulation.
11913616 - Current guidelines in heart failure management.
24024196 - Bronchial responsiveness in patients with restrictive spirometry.
2930306 - Incidence of residual defects determining the clinical outcome after correction of tetr...
Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  74     ISSN:  1347-4820     ISO Abbreviation:  Circ. J.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  2118-24     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular and Respiratory Medicine, Akita University Graduate School of Medicine, Akita, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Comments/Corrections
Comment In:
Circ J. 2010 Oct;74(10):2056-7   [PMID:  20838005 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Predictors of electrical storm in patients with idiopathic dilated cardiomyopathy--how to stratify t...
Next Document:  Comparison of plain balloon and cutting balloon angioplasty for the treatment of restenosis with dru...