Document Detail


Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination.
MedLine Citation:
PMID:  20568990     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium. CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury.
Authors:
Mukaddes Eşrefoğlu; Cengiz Ara
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrastructural pathology     Volume:  34     ISSN:  1521-0758     ISO Abbreviation:  Ultrastruct Pathol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-08     Completed Date:  2011-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002867     Medline TA:  Ultrastruct Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
Affiliation:
Department of Histology and Embryology, Inonu University, Malatya, Turkey. drmukaddes@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / pharmacology*
Bile Ducts / surgery
Caffeic Acids / pharmacology*
Cholestasis / etiology,  pathology*
Hepatocytes / drug effects*,  ultrastructure*
Ligation
Liver / drug effects,  injuries,  ultrastructure
Liver Diseases / drug therapy,  etiology,  pathology
Male
Microscopy, Electron, Transmission
Phenylethyl Alcohol / analogs & derivatives*,  pharmacology
Rats
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Caffeic Acids; 104594-70-9/caffeic acid phenethyl ester; 60-12-8/Phenylethyl Alcohol

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