| Beneficial effect of caffeic acid phenethyl ester (CAPE) on hepatocyte damage induced by bile duct ligation: an electron microscopic examination. | |
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MedLine Citation:
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PMID: 20568990 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recently the authors have reported the potent beneficial effect of caffeic acid phenethyl ester (CAPE) on cholestatic oxidative liver injury induced by acute bile ligation in Swiss albino rats. Herein, they report the ultrastructural hepatocellular alterations induced by acute bile duct ligation and the effect of CAPE administration on these alterations. Bile duct ligation resulted in many degenerative changes, such as vacuolization, mitochondrial degeneration, endoplasmic reticulum dilatation, and lysosome accumulation within the cytoplasm of hepatocytes. Mitochondrial degeneration was also observed within the cytoplasm of the cells of biliary ductular epithelium. CAPE potentially protected the hepatocytes from the cholestasis-induced cellular injury. |
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Authors:
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Mukaddes Eşrefoğlu; Cengiz Ara |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Ultrastructural pathology Volume: 34 ISSN: 1521-0758 ISO Abbreviation: Ultrastruct Pathol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-08 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8002867 Medline TA: Ultrastruct Pathol Country: England |
Other Details:
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Languages: eng Pagination: 273-8 Citation Subset: IM |
Affiliation:
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Department of Histology and Embryology, Inonu University, Malatya, Turkey. drmukaddes@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / pharmacology* Bile Ducts / surgery Caffeic Acids / pharmacology* Cholestasis / etiology, pathology* Hepatocytes / drug effects*, ultrastructure* Ligation Liver / drug effects, injuries, ultrastructure Liver Diseases / drug therapy, etiology, pathology Male Microscopy, Electron, Transmission Phenylethyl Alcohol / analogs & derivatives*, pharmacology Rats |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Caffeic Acids; 104594-70-9/caffeic acid phenethyl ester; 60-12-8/Phenylethyl Alcohol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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