Document Detail


Beneficial 2-years results of drug-eluting stents in saphenous vein graft lesions.
MedLine Citation:
PMID:  19112787     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: There are limited data regarding clinical outcomes of drug-eluting stents (DES) in saphenous vein grafts (SVGs) compared to bare metal stents (BMS). Here we compared outcomes of DES in de novo SVG lesions versus BMS in contemporary percutaneous coronary intervention (PCI). METHODS AND RESULTS: We compared in-hospital, 6-month, 1-year and two years outcomes in 68 patients (72 grafts) who underwent PCI of SVG lesions using DES and a control BMS group composed of 43 patients (46 grafts) who underwent angioplasty in de novo SVG lesions. Major adverse cardiac events (MACE) included death, myocardial infarction (MI), target lesion revascularisation (TLR), and target vessel revascularisation (TVR). The rates of TLR and TVR at the 1-year evaluation were lower in the DES group than the BMS group (TLR per patient, 7.4% vs. 21%, P=0.04; TVR per patient, 10.3% vs. 23.3%, P=0.1). MACE-free survival was 88.2% in the DES group and 69.8% in the BMS group (P=0.02). At two years clinical follow-up: death 2.9% vs. 4.7% (P=0.6); MI: 8.8% vs. 7% (P=0.6). The rates of TLR and TVR were significantly lower in the DES group compared to the BMS group (TLR per patient, 14.7% vs. 32.6%, P=0.03; TVR per patient, 10.3% vs. 27.9%, P=0.02). The rate of MACE-free survival was 79.4% in the DES group and 58.1% in the BMS group (P=0.02). Between one to two years after PCI, no cases of angiographic stent thrombosis were recorded in either group. CONCLUSIONS: DES implantation in SVG lesions was safe and had favourable outcomes after two years without excess cardiac mortality.
Authors:
Abid Assali; Yael Raz; Hana Vaknin-Assa; Itsik Ben-Dor; David Brosh; Igal Teplitsky; Shmuel Fuchs; Ran Kornowski
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  4     ISSN:  1774-024X     ISO Abbreviation:  -     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-12-30     Completed Date:  2009-02-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  108-14     Citation Subset:  IM    
Affiliation:
Cardiac Catheterisation Laboratories, Department of Cardiology, Rabin Medical Center, Petach Tikva, Israel.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angioplasty, Transluminal, Percutaneous Coronary* / mortality
Coronary Angiography
Coronary Artery Disease / mortality,  radiography,  therapy*
Coronary Restenosis / mortality,  radiography,  therapy*
Drug-Eluting Stents*
Female
Follow-Up Studies
Graft Occlusion, Vascular / mortality,  therapy*
Humans
Logistic Models
Male
Metals
Middle Aged
Myocardial Infarction / mortality
Retrospective Studies
Saphenous Vein / transplantation*
Survival Rate
Treatment Outcome
Chemical
Reg. No./Substance:
0/Metals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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