Document Detail


Bendavia, a mitochondria-targeting peptide, improves post-infarction cardiac function, prevents adverse left ventricular remodeling and restores mitochondria-related gene expression in rats.
MedLine Citation:
PMID:  25165999     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
: We evaluated the post-myocardial infarction (MI) therapeutic effects of Bendavia. Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n=28) or water (n=26). Six weeks later, Bendavia significantly reduced scar circumference (39.7 ± 2.2 %) compared to water treatment (47.4 ± 0.03 %, p=0.024); and reduced left ventricular (LV) volume by 8.9% (p=0.0019). LV fractional shortening was significantly improved by Bendavia (28.8 ± 1.7 %) compared to water treatment (23.8 ± 1.8 %, p=0.047). LV ejection fraction was higher with Bendavia (55.3 ± 1.4%) than water treatment (49.3 ± 1.4%, p=0.005). Apoptosis, within the MI border zone, was significantly less in the Bendavia group (32 ± 3%, n=12) compared to the water group (41 ± 2%, n=12; p=0.029). Bendavia reversed mitochondrial function-related gene expression in the MI border, which was largely reduced in water-treated rats. Bendavia improved complex-I and -IV activity, and reduced reactive oxygen species production and cytosolic cytochrome c level in the peri-infarcted region. Bendavia improved post-MI cardiac function, prevented infarct expansion and adverse LV remodeling, and restored mitochondria-related gene expression, complex-I and -IV activity, and reduced reactive oxygen species and cardiomyocyte apoptosis in the noninfarcted MI border.
Authors:
Wangde Dai; Jianru Shi; Ramesh C Gupta; Hani N Sabbah; Sharon L Hale; Robert A Kloner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-27
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  -     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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