Document Detail


Benchtop-NMR and MRI--a new analytical tool in drug delivery research.
MedLine Citation:
PMID:  18930126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During the last years, NMR spectroscopy and NMR imaging (magnetic resonance imaging, MRI) have been increasingly used to monitor drug delivery systems in vitro and in vivo. However, high installation and running costs of the commonly used superconducting magnet technology limits the application range and prevents the further spread of this non-invasive technology. Benchtop-NMR (BT-NMR) relaxometry uses permanent magnets and is much less cost intensive. BT-NMR relaxometry is commonly used in the food and chemical industry, but so far scarcely used in the pharmaceutical field. The paper shows on several examples that the application field of BT-NMR relaxometry can be extended into the field of drug delivery, including the characterisation of emulsions and lipid ingredients (e.g. the amount and physicochemical state of the lipid) and the monitoring of adsorption characteristics (e.g. oil binding of porous ingredients). The most exciting possibilities of BT-NMR technology are linked with the new development of BT-instruments with imaging capability. BT-MRI examples on the monitoring of hydration and swelling of HPMC-based monolayer and double-layer tablets are shown. BT-MRI opens new MRI opportunities for the non-invasive monitoring of drug delivery processes.
Authors:
Hendrik Metz; Karsten Mäder
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-09-26
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  364     ISSN:  0378-5173     ISO Abbreviation:  Int J Pharm     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  170-5     Citation Subset:  IM    
Affiliation:
Institute of Pharmacy, Martin Luther University, Wolfgang-Langenbeck Str. 4, 06120 Halle Saale, Germany.
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical
Costs and Cost Analysis
Dosage Forms
Drug Delivery Systems
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / economics,  methods*
Pharmaceutical Preparations / administration & dosage*
Technology, Pharmaceutical / methods
Chemical
Reg. No./Substance:
0/Dosage Forms; 0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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