| Prediction of nonspecific side effects in rheumatoid arthritis patients by beliefs about medicines. | |
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MedLine Citation:
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PMID: 20191574 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study examines the determinants of patients' side effects from arthritis medication. Proposed predictors were patients' beliefs about medications, objective disease activity, treatment regimen, and psychiatric and rheumatoid arthritis symptoms. METHODS: In a longitudinal design, 100 rheumatoid arthritis outpatients were investigated at baseline and again at 6 months after receiving both pharmacologic and psychosocial treatment. RESULTS: Multivariate analyses showed no influence of disease status, type of treatment, or psychiatric or arthritis symptoms on side effects. Heightened concerns about arthritis medication at baseline predicted side effects at baseline (partial correlation r = 0.37, P < 0.001) and at 6 months (partial correlation r = 0.25, P < 0.001) after controlling for relevant disease- and treatment-related variables. In a cross-lagged panel analysis, prior experience with side effects from arthritis medication was ruled out as a cause of heightened concerns, indicating that negative beliefs genuinely contribute to side effects. A comparison of patients who did and did not start new medications showed no difference in side effects in patients with positive beliefs about medications, but led to significantly more side effects in patients with negative beliefs. CONCLUSION: Patients' beliefs about arthritis medications were stable and consistently associated with side effects. Patients with greater concerns about their arthritis medications are at higher risk for developing side effects, especially when starting new drugs. Identifying those patients is important to avoid premature drug discontinuation. Research into cause and preventability of negative attitudes to prescribed medicines is needed. |
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Authors:
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Yvonne Nestoriuc; E John Orav; Matthew H Liang; Robert Horne; Arthur J Barsky |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Arthritis care & research Volume: 62 ISSN: 2151-4658 ISO Abbreviation: Arthritis Care Res (Hoboken) Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-06-30 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101518086 Medline TA: Arthritis Care Res (Hoboken) Country: United States |
Other Details:
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Languages: eng Pagination: 791-9 Citation Subset: IM |
Affiliation:
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Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antirheumatic Agents / adverse effects* Arthritis, Rheumatoid / drug therapy*, psychology* Cognitive Therapy / methods Cohort Studies Culture* Female Follow-Up Studies Health Knowledge, Attitudes, Practice* Humans Longitudinal Studies Male Middle Aged Predictive Value of Tests Registries Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR047014-01A1/AR/NIAMS NIH HHS; R01-AR-4701401/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antirheumatic Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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