Document Detail

Behind heart failure syndrome: remember AL amyloidosis. Two case-reports.
MedLine Citation:
PMID:  21309362     Owner:  NLM     Status:  In-Process    
Amyloidosis is a systemic disease that is a consequence of extracellular deposition of insoluble fibrils composed of subunits of low molecular weight (5-25 kD) derived from a variety of plasma proteins. Identification of the amyloidogenic protein determines the type of amyloidosis. In primary systemic amyloidosis (classically called AL amyloidosis), the amyloid protein is composed of light chains resulting from plasma-cell dyscrasia. Cardiac manifestations are the most common clinical presentation of this type of amyloidosis, occurring in 50% of patients. The authors describe two cases in which hospitalization was due to decompensated heart failure, which were similar in their etiology (multiple myeloma/amyloid cardiomyopathy) and evolution (sudden death). The authors wish to draw attention to an entity that is rarely encountered in clinical practice and that requires a high index of suspicion.
Doroteia Silva; Luís Sargento; Manuel Gato Varela; Dulce Brito; Mário G Lopes
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology     Volume:  29     ISSN:  0870-2551     ISO Abbreviation:  Rev Port Cardiol     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-02-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710716     Medline TA:  Rev Port Cardiol     Country:  Portugal    
Other Details:
Languages:  eng; por     Pagination:  1751-9     Citation Subset:  IM    
Serviço de Cardiologia I, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, EPE, Lisboa, Portugal.
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