Document Detail

Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training.
MedLine Citation:
PMID:  15851714     Owner:  NLM     Status:  MEDLINE    
Persistent low-grade inflammation, as indicated by higher circulating levels of inflammatory mediators such as C-reactive protein, interleukin-6 and tumour necrosis factor-alpha, is a strong risk factor for several chronic diseases. There are data indicating that decreasing energy intake and increasing physical activity may be effective therapies for reducing overall inflammation. Evidence is strong that circulating levels of inflammatory markers are elevated with total and abdominal obesity, possibly owing to a higher secretion rate of cytokines by adipose tissue in obese people. Moreover, very-low-energy dietary weight loss reduces both circulating markers of inflammation and adipose-tissue cytokine production. Data from several large population-based cohorts show an inverse association between markers of systemic inflammation and physical activity or fitness status; small-scale intervention studies support that exercise training diminishes inflammation. Dietary weight loss plus exercise is likely more effective than weight reduction alone in reducing inflammation. To date, data from randomized, controlled trails designed to definitively test the effects of weight loss or exercise training, or both, on inflammation are limited. Future studies are required to define the amount of weight loss needed for clinically meaningful reductions of inflammation; in addition, fully powered and controlled studies are necessary to clarify the effect of exercise training on chronic, systemic inflammation.
Barbara J Nicklas; Tongjian You; Marco Pahor
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  172     ISSN:  1488-2329     ISO Abbreviation:  CMAJ     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-10-06     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1199-209     Citation Subset:  AIM; IM    
Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
C-Reactive Protein / metabolism*
Cytokines / blood
Exercise / physiology*
Health Behavior*
Inflammation / blood,  physiopathology,  therapy*
Obesity / blood
Weight Loss / physiology*
Grant Support
P30-AG-021332/AG/NIA NIH HHS; R01-AG/DK-20583/AG/NIA NIH HHS
Reg. No./Substance:
0/Cytokines; 9007-41-4/C-Reactive Protein
Comment In:
CMAJ. 2005 Oct 25;173(9):1066   [PMID:  16247106 ]

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