Document Detail


Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training.
MedLine Citation:
PMID:  15851714     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Persistent low-grade inflammation, as indicated by higher circulating levels of inflammatory mediators such as C-reactive protein, interleukin-6 and tumour necrosis factor-alpha, is a strong risk factor for several chronic diseases. There are data indicating that decreasing energy intake and increasing physical activity may be effective therapies for reducing overall inflammation. Evidence is strong that circulating levels of inflammatory markers are elevated with total and abdominal obesity, possibly owing to a higher secretion rate of cytokines by adipose tissue in obese people. Moreover, very-low-energy dietary weight loss reduces both circulating markers of inflammation and adipose-tissue cytokine production. Data from several large population-based cohorts show an inverse association between markers of systemic inflammation and physical activity or fitness status; small-scale intervention studies support that exercise training diminishes inflammation. Dietary weight loss plus exercise is likely more effective than weight reduction alone in reducing inflammation. To date, data from randomized, controlled trails designed to definitively test the effects of weight loss or exercise training, or both, on inflammation are limited. Future studies are required to define the amount of weight loss needed for clinically meaningful reductions of inflammation; in addition, fully powered and controlled studies are necessary to clarify the effect of exercise training on chronic, systemic inflammation.
Authors:
Barbara J Nicklas; Tongjian You; Marco Pahor
Related Documents :
19293164 - Exercise prescription for the overweight and the obese: how to quantify and yet keep it...
11601564 - Effects of long versus short bout exercise on fitness and weight loss in overweight fem...
6768354 - Is the weight loss of hyperbaric habitation a disorder of osmoregulation?
3343914 - Exercise capacity and nitrogen loss during a high or low carbohydrate diet.
25216614 - Cardiac rehabilitation in the elderly.
2105684 - Analysis of refractory period after exercise and eucapnic voluntary hyperventilation ch...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  172     ISSN:  1488-2329     ISO Abbreviation:  CMAJ     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-26     Completed Date:  2005-10-06     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  1199-209     Citation Subset:  AIM; IM    
Affiliation:
Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. bnicklas@wfubmc.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
C-Reactive Protein / metabolism*
Cytokines / blood
Exercise / physiology*
Health Behavior*
Humans
Inflammation / blood,  physiopathology,  therapy*
Obesity / blood
Weight Loss / physiology*
Grant Support
ID/Acronym/Agency:
P30-AG-021332/AG/NIA NIH HHS; R01-AG/DK-20583/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 9007-41-4/C-Reactive Protein
Comments/Corrections
Comment In:
CMAJ. 2005 Oct 25;173(9):1066   [PMID:  16247106 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarct...
Next Document:  Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale.