Document Detail

Behavioural significance of prolactin signalling in the central nervous system during pregnancy and lactation.
MedLine Citation:
PMID:  11914112     Owner:  NLM     Status:  MEDLINE    
The role of prolactin in the regulation of mammary gland development and function during pregnancy and lactation is well established. However, in addition, prolactin appears to have a much wider role in the physiology of lactation. There is widespread expression of prolactin receptors in the hypothalamus during lactation, indicative of a multi-faceted role for prolactin in regulating hypothalamic function. During pregnancy and lactation, the maternal brain undergoes structural and functional modification, allowing the establishment of appropriate behaviour to feed and nurture the offspring, to adjust to the nutritional and metabolic demands of milk production, and to maintain appropriate hormone secretion to allow milk synthesis, secretion and ejection. The coordination of such a range of neurobiological and neuroendocrine adaptations requires an endocrine signalling mechanism, capable of communicating the reproductive state to the brain. Evidence indicates that prolactin is part of this mechanism.
David R Grattan
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Reproduction (Cambridge, England)     Volume:  123     ISSN:  1470-1626     ISO Abbreviation:  Reproduction     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-08-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100966036     Medline TA:  Reproduction     Country:  England    
Other Details:
Languages:  eng     Pagination:  497-506     Citation Subset:  IM    
Department of Anatomy and Structural Biology, School of Medical Sciences and Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
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MeSH Terms
Hypothalamus / metabolism*
Lactation / physiology*
Maternal Behavior*
Placenta / metabolism
Placental Lactogen / metabolism
Pregnancy / metabolism*
Prolactin / physiology*
Receptors, Prolactin / metabolism
Signal Transduction / physiology*
Stress, Psychological
Reg. No./Substance:
0/Receptors, Prolactin; 9002-62-4/Prolactin; 9035-54-5/Placental Lactogen

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