Document Detail

Behavioural and physiological effects of electrical stimulation in the nucleus accumbens: a review.
MedLine Citation:
PMID:  17691326     Owner:  NLM     Status:  MEDLINE    
Electrical stimulation (ES) in the brain is becoming a new treatment option in patients with treatment-resistant obsessive-compulsive disorder (OCD). A possible brain target might be the nucleus accumbens (NACC). This review aims to summarise the behavioural and physiological effects of ES in the NACC in humans and in animals and to discuss these findings with regard to neuroanatomical, electrophysiological and behavioural insights. The results clearly demonstrate that ES in the NACC has an effect on reward, activity, fight-or-flight, exploratory behaviour and food intake, with evidence for only moderate physiological effects. Seizures were rarely observed. Finally, the results of ES studies in patients with treatment-resistant OCD and in animal models for OCD are promising.
K van Kuyck; L Gabriëls; P Cosyns; L Arckens; V Sturm; S Rasmussen; B Nuttin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  97     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-09-26     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  375-91     Citation Subset:  IM    
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MeSH Terms
Behavior, Animal / physiology,  radiation effects*
Disease Models, Animal
Eating / physiology,  radiation effects
Electric Stimulation / methods*
Exploratory Behavior / physiology,  radiation effects
Nucleus Accumbens / physiology*,  radiation effects*
Obsessive-Compulsive Disorder / therapy

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