Document Detail

Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks.
MedLine Citation:
PMID:  22683919     Owner:  NLM     Status:  Publisher    
Behavioural effects of fluvoxamine (FLV, selective serotonin reuptake inhibitor) were examined in 1-2 week old domestic chicks. Chicks were tested in an I-shaped maze equipped with a feeder (ON feeder) that served 1 or 2 grains of millet at gradually increasing intervals, so that a depleting food patch was mimicked. By leaving the feeder, the food delivery program was reset, and chicks gained food at short intervals only after a travel to a dummy feeder (OFF feeder) placed on the opposite side of the maze. Chicks quickly learned to actively shuttle between the ON and the OFF feeders. FLV (intra-peritoneal injection, 20mg/kg BW) acutely caused chicks to stay longer at the gradually depleting ON feeder. Inter-temporal choices were also tested, whereby two colored beads were simultaneously presented, each associated with a small/short-delay reward or a large/long-delay alternative. FLV suppressed the choice of the short-delay option. It is suggested that an enhanced level of serotonin (5-HT) makes chicks more tolerant of the delayed food item in both behavioural paradigms. Furthermore, the decision to leave a depleting patch cannot be equated to choosing the long-delay option of the choice paradigm. Furthermore, FLV suppressed work efforts (velocity and running distance) in uncued shuttle and number of distress calls. In vivo microdialysis experiments revealed that FLV enhanced the extracellular concentration of 5-HT as well as dopamine (DA) locally in the medial striatum/nucleus accumbens. Underlying neuromodulatory mechanisms of behavioural control are examined in relation to locomotion, behavioural tolerance and interval timing.
Shohei Matsunami; Yukiko Ogura; Hidetoshi Amita; Takeshi Izumi; Mitsuhiro Yoshioka; Toshiya Matsushima
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-6
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Biology, Faculty of Science, Hokkaido University, N10-W8, Kita-ku, Sapporo, 060-0810 Japan.
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