Document Detail


Behavioural parameters in hypertensives on atenolol therapy.
MedLine Citation:
PMID:  10645693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behavioural responses which included psychological tests and cold pressor test as a stress test were studied in 20 mild to moderate hypertensives of both sexes, excluding smokers, alcoholics, secondary hypertensives and patients of chronic obstructive pulmonary diseases. Subjects were put on 2 weeks of placebo washout period followed by 6 weeks of treatment with atenolol. Following treatment with atenolol they showed no significant alteration in the scores of psychological tests which included Weschler adult intelligence scale for orientation, while showing significant depression in the rise of heart rate, systolic blood pressure and diastolic blood pressure following cold pressor test. On further analysis, the results showed that hypertensives on placebo had lower scores of memory and attention test as compared to normotensive controls. Besides this, hypertensives on placebo had higher rise of heart rate and systolic blood pressure as compared to normotensive controls after cold pressor test.
Authors:
M Chaswal; S Singh; N Shankar; R Avasthi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the Indian Medical Association     Volume:  97     ISSN:  0019-5847     ISO Abbreviation:  J Indian Med Assoc     Publication Date:  1999 Jun 
Date Detail:
Created Date:  2000-02-04     Completed Date:  2000-02-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7505608     Medline TA:  J Indian Med Assoc     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  214-6, 232     Citation Subset:  IM    
Affiliation:
Department of Physiology, University College of Medical Sciences and GTB Hospital, Delhi.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology,  therapeutic use*
Adult
Antihypertensive Agents / pharmacology,  therapeutic use*
Atenolol / pharmacology,  therapeutic use*
Attention / drug effects
Behavior* / drug effects
Blood Pressure / drug effects,  physiology
Cold Temperature / diagnostic use
Female
Heart Rate / drug effects
Humans
Hypertension / diagnosis,  drug therapy*,  psychology*
Intelligence Tests
Male
Memory / drug effects
Mental Status Schedule
Middle Aged
Placebos
Questionnaires
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Placebos; 29122-68-7/Atenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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