Document Detail


Behavioural hypertension in sodium-loaded dogs is accompanied by sustained sodium retention.
MedLine Citation:
PMID:  3584968     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Instrumented dogs were presented with two daily avoidance conditioning sessions during 12 days of continuous saline infusion (1.3 l/day). Avoidance conditioning of sodium-loaded dogs resulted in progressive 24-h hypertension over the 12-day conditioning periods (systolic, 21 +/- 3 mmHg; diastolic, 15 +/- 1 mmHg) accompanied by a decreased 24-h heart rate (-14.8 +/- 4.0 beats/min). Under these conditions, renal excretion of sodium decreased relative to sodium intake (-88 +/- 19 mmol/12 days) while urine volume was increased relative to water intake (0.18 +/- 0.07 l/day). The sodium retention was accompanied by increased plasma sodium levels (1.8 +/- 0.7 mmol/l) and decreased plasma calcium levels (-1.2 +/- 0.2 mmol/l). Daily creatinine clearance decreased during the development of hypertension (-53 +/- 13% per day). Subsequently, each dog was exposed to 12 days of saline infusion in the absence of avoidance sessions. Under these conditions, arterial pressure and sodium balance remained stable. It was concluded that the rapidly developing and reversible hypertension occurring in sodium-loaded dogs exposed to recurrent behavioural stress is mediated by increased levels of total body sodium.
Authors:
D E Anderson; J R Dietz; P Murphy
Related Documents :
1791608 - The role of sex hormones and sodium intake in postmenopausal hypertension.
11530718 - Respiratory psychophysiology in hypertension research.
2157758 - The relation of blood sodium concentration to blood pressure in the rat.
11330878 - Bezafibrate reduces heart rate and blood pressure in patients with hypertriglyceridemia.
18830578 - Arterial pressure changes during the valsalva maneuver to predict fluid responsiveness ...
9973038 - Cardiorespiratory responses to negative pressure ventilation after tetralogy of fallot ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  5     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Creatinine / metabolism
Dogs
Female
Glomerular Filtration Rate / drug effects
Heart Rate / drug effects
Hypertension / etiology,  metabolism*,  physiopathology
Kidney / physiopathology
Potassium / metabolism
Sodium / metabolism*
Stress, Physiological / complications*
Time Factors
Grant Support
ID/Acronym/Agency:
H101138//PHS HHS; HL28462/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Relationship of 24-hour blood pressure mean and variability to severity of target-organ damage in hy...
Next Document:  Defective lymphopoiesis in the bone marrow of motheaten (me/me) and viable motheaten (mev/mev) mutan...