Document Detail

Behavioural hypertension in sodium-loaded dogs is accompanied by sustained sodium retention.
MedLine Citation:
PMID:  3584968     Owner:  NLM     Status:  MEDLINE    
Instrumented dogs were presented with two daily avoidance conditioning sessions during 12 days of continuous saline infusion (1.3 l/day). Avoidance conditioning of sodium-loaded dogs resulted in progressive 24-h hypertension over the 12-day conditioning periods (systolic, 21 +/- 3 mmHg; diastolic, 15 +/- 1 mmHg) accompanied by a decreased 24-h heart rate (-14.8 +/- 4.0 beats/min). Under these conditions, renal excretion of sodium decreased relative to sodium intake (-88 +/- 19 mmol/12 days) while urine volume was increased relative to water intake (0.18 +/- 0.07 l/day). The sodium retention was accompanied by increased plasma sodium levels (1.8 +/- 0.7 mmol/l) and decreased plasma calcium levels (-1.2 +/- 0.2 mmol/l). Daily creatinine clearance decreased during the development of hypertension (-53 +/- 13% per day). Subsequently, each dog was exposed to 12 days of saline infusion in the absence of avoidance sessions. Under these conditions, arterial pressure and sodium balance remained stable. It was concluded that the rapidly developing and reversible hypertension occurring in sodium-loaded dogs exposed to recurrent behavioural stress is mediated by increased levels of total body sodium.
D E Anderson; J R Dietz; P Murphy
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hypertension     Volume:  5     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-06-26     Completed Date:  1987-06-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-105     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Creatinine / metabolism
Glomerular Filtration Rate / drug effects
Heart Rate / drug effects
Hypertension / etiology,  metabolism*,  physiopathology
Kidney / physiopathology
Potassium / metabolism
Sodium / metabolism*
Stress, Physiological / complications*
Time Factors
Grant Support
Reg. No./Substance:
60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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