| Behavioural exposure and sleep do not modify corticospinal and intracortical excitability in the human motor system. | |
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MedLine Citation:
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PMID: 20064743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Behavioural exposure and sleep may bidirectionally modify the excitability of cortical networks including those in the motor cortex. Here we tested whether the excitability of intracortical inhibitory and excitatory networks within the primary motor cortex exhibited changes suggestive of a time of day influence. METHODS: Short-interval intracortical inhibition (SICI) and facilitation (ICF), and input-output curves (IO curves) were investigated using transcranial magnetic stimulation (TMS). Recordings were made from the resting right first dorsal interosseous (FDI) muscle in 10 healthy subjects on three occasions: 9A.M. and 4P.M. of the same day, and 9A.M. of the following day. RESULTS: There was no significant change in any of the measures across the three assessments. CONCLUSIONS: These findings provide evidence that time of day does not significantly influence corticospinal and intracortical excitability in the primary motor cortex. SIGNIFICANCE: These results provide no support for the hypothesis that synapses within the motor cortex undergo potentiation due to daytime use and behavioural experiences. Additionally, these findings provide evidence that measurement of motor cortical excitability is not systematically biased by time-of-day dependent variability and thus does not pose a confound in studies assessing corticospinal excitability longitudinally. |
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Authors:
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Sebastian H Doeltgen; Michael C Ridding |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-12 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 121 ISSN: 1872-8952 ISO Abbreviation: Clin Neurophysiol Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 448-52 Citation Subset: IM |
Affiliation:
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The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia. sebastian.doeltgen@adelaide.edu.au |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Behavior / physiology* Circadian Rhythm / physiology* Environment Environment, Controlled Evoked Potentials, Motor / physiology Excitatory Postsynaptic Potentials / physiology Female Humans Inhibitory Postsynaptic Potentials / physiology Male Motor Cortex / physiology* Movement / physiology Nerve Net / physiology Neural Inhibition / physiology Neuronal Plasticity / physiology* Psychomotor Performance / physiology Pyramidal Tracts / physiology* Sleep / physiology* Synaptic Transmission / physiology Transcranial Magnetic Stimulation Wakefulness / physiology Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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