| Behavioural cues are associated with modulations of synchronous oscillations in the human subthalamic nucleus. | |
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MedLine Citation:
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PMID: 12847073 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The speed with which one reacts to an imperative signal depends on the extent to which preceding cues predict that command. When reliable warning cues are available, the processing of the imperative stimulus can be favoured and responses partially pre-prepared, leading to shorter reaction times. Here we seek evidence for involvement of the human basal ganglia in the exploitation of behaviourally relevant predictive cues. To this end, local field potentials (LFPs) were recorded in the region of the subthalamic nuclei of parkinsonian patients during the performance of a pre-cued reaction task in which the cue either predicted or failed to predict the demands of the imperative signal. We demonstrate that LFP activity in the beta frequency band ( approximately 20 Hz) is modulated by the behavioural relevance of the external cue. The findings suggest that, first, the subthalamic nucleus is involved in mediating or facilitating the response advantage derived from predictive cues in humans and, secondly, variations in synchronous neuronal activity in the beta band may contribute to this function in the subthalamic nucleus. |
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Authors:
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David Williams; Andrea Kühn; Andreas Kupsch; Marina Tijssen; Gerard van Bruggen; Hans Speelman; Gary Hotton; Kielan Yarrow; Peter Brown |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-07-07 |
Journal Detail:
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Title: Brain : a journal of neurology Volume: 126 ISSN: 0006-8950 ISO Abbreviation: Brain Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-25 Completed Date: 2003-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372537 Medline TA: Brain Country: England |
Other Details:
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Languages: eng Pagination: 1975-85 Citation Subset: AIM; IM |
Affiliation:
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Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Basal Ganglia / physiopathology Biological Clocks* Cues* Electroencephalography Female Humans Male Middle Aged Parkinson Disease / physiopathology, psychology* Photic Stimulation / methods Reaction Time Signal Processing, Computer-Assisted Subthalamic Nucleus / physiopathology* |
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