Document Detail

Behavioural and cardiovascular responses of rats to euthanasia using carbon dioxide gas.
MedLine Citation:
PMID:  9350705     Owner:  NLM     Status:  MEDLINE    
Our results showed more rapid falls in pulse rate and blood pressure in rats euthanized in a chamber precharged with carbon dioxide (CO2), when compared with rats euthanized more slowly, but death still took over 5 min in the former group. There was no behavioural evidence of pain or distress in either group during euthanasia. Initial ataxia and dyspnoea was punctuated by a lag before death, thus separating euthanasia into three clearly defined phases. All visual signs of death preceded complete vascular collapse by about 1 min in both groups, so we recommend that gas flow be maintained for at least 1 min after apparent death.
W Smith; S B Harrap
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animals     Volume:  31     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  337-46     Citation Subset:  IM    
Department of Science and Technology, Western Melbourne Institute of Technical and Further Education, Footscray, Victoria, Australia.
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MeSH Terms
Administration, Inhalation
Animal Welfare
Atmosphere Exposure Chambers
Behavior, Animal / drug effects*
Blood Pressure / drug effects
Carbon Dioxide / analysis,  toxicity*
Cardiovascular System / drug effects*,  physiopathology
Heart Rate / drug effects
Rats, Sprague-Dawley
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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