Document Detail

Behavioural and cardiovascular responses of rats to euthanasia using carbon dioxide gas.
MedLine Citation:
PMID:  9350705     Owner:  NLM     Status:  MEDLINE    
Our results showed more rapid falls in pulse rate and blood pressure in rats euthanized in a chamber precharged with carbon dioxide (CO2), when compared with rats euthanized more slowly, but death still took over 5 min in the former group. There was no behavioural evidence of pain or distress in either group during euthanasia. Initial ataxia and dyspnoea was punctuated by a lag before death, thus separating euthanasia into three clearly defined phases. All visual signs of death preceded complete vascular collapse by about 1 min in both groups, so we recommend that gas flow be maintained for at least 1 min after apparent death.
W Smith; S B Harrap
Related Documents :
11973845 - Effect of reduced barometric pressure on water availability related to microbial growth.
4054085 - Diagnostic value of contrast echocardiography in the horse.
14982645 - Aspiration of dead space in the management of chronic obstructive pulmonary disease pat...
11029345 - Tromethamine buffer modifies the depressant effect of permissive hypercapnia on myocard...
18530715 - Correlation of vasoconstriction and kidney protection during shock wave lithotripsy.
7364055 - Microcirculatory actions of general anesthetics.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animals     Volume:  31     ISSN:  0023-6772     ISO Abbreviation:  Lab. Anim.     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1997-11-20     Completed Date:  1997-11-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0112725     Medline TA:  Lab Anim     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  337-46     Citation Subset:  IM    
Department of Science and Technology, Western Melbourne Institute of Technical and Further Education, Footscray, Victoria, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Inhalation
Animal Welfare
Atmosphere Exposure Chambers
Behavior, Animal / drug effects*
Blood Pressure / drug effects
Carbon Dioxide / analysis,  toxicity*
Cardiovascular System / drug effects*,  physiopathology
Heart Rate / drug effects
Rats, Sprague-Dawley
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Extrusion of earthworm coelomocytes: comparison of the cell populations recovered from the species L...
Next Document:  Hypoxia-induced pulmonary hypertension in an optimized environment for the guineapig.