Document Detail


Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties.
MedLine Citation:
PMID:  12832098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Melanin-concentrating hormone (MCH) is a cyclic neuropeptide, predominantly expressed in hypothalamus, and recognized as a key regulator in feeding behaviour and energy balance. In this study, we examined the behavioural effects of intracerebroventricularly administered MCH on food intake, anxiety, exploratory behaviour and body core temperature in rats. MCH (0.15-10.0 microg, i.c.v.) acutely increased food intake in a dose-dependent manner. In addition, MCH (0.6-10.0 microg, i.c.v.) produced effects similar to anxiolytics in an animal model of anxiety, Vogel's punished drinking test. Thus, punished drinking episodes were significantly increased. We found no effects of MCH (5.0-20.0 microg, i.c.v.) on locomotor activity either in habituated or non-habituated animals. Furthermore, MCH did not produce any changes in body core temperature. Together, these observations further support a role for MCH as an orexigenic neuropeptide and also suggest anti-anxiety properties for MCH.
Authors:
Johanna Kela; Peter Salmi; Roberto Rimondini-Giorgini; Markus Heilig; Claes Wahlestedt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Regulatory peptides     Volume:  114     ISSN:  0167-0115     ISO Abbreviation:  Regul. Pept.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-06-30     Completed Date:  2004-04-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  IM    
Affiliation:
Center for Genomics and Bioinformatics, Karolinska Institutet, Berzelius väg 35, SE-171 77 Stockholm, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / physiopathology*
Behavior, Animal / physiology*
Body Temperature / physiology
Hypothalamic Hormones / physiology*
Male
Melanins / physiology*
Pituitary Hormones / physiology*
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Hypothalamic Hormones; 0/Melanins; 0/Pituitary Hormones; 67382-96-1/melanin-concentrating hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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