| Behavioural Modification of the Cholinergic Anti-inflammatory Response to C-Reactive Protein in Patients with Hypertension. | |
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MedLine Citation:
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PMID: 22292421 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: A central hypothesis of the cholinergic anti-inflammatory reflex model is that innate immune activity is inhibited by the efferent vagus. We evaluated whether changes in markers of tonic or reflex vagal-heart rate modulation following behavioural intervention were associated inversely with changes in high sensitivity C-reactive protein (hsCRP) or interleukin-6 (IL-6). Design: Subjects diagnosed with hypertension (n=45, age 35-64 years, 53% female) were randomized to an 8-week protocol of behavioural neurocardiac training (with heart rate variability biofeedback) or autogenic relaxation. Assessments before and after intervention included pro-inflammatory factors (hsCRP, IL-6), markers of vagal-heart rate modulation (RR high frequency [HF] power within 0.15-0.40 Hz, baroreflex sensitivity and RR interval), conventional measures of lipoprotein cholesterol, and 24hour ambulatory systolic and diastolic blood pressure. Results: Changes in hsCRP and IL-6 were not associated with changes in lipoprotein cholesterol or blood pressure. After adjusting for anti-inflammatory drugs and confounding factors, changes in hsCRP related inversely to changes in HF power (ß = -0.25±0.1, p=0.02), baroreflex sensitivity (ß = -0.33±0.7, p=0.04) and RR interval (ß = -0.001 ±0.0004, p=0.02). Statistically significant relationships were not observed for IL-6. Conclusions: Changes in hsCRP were consistent with the inhibitory effect of increased vagal efferent activity on pro-inflammatory factors predicted by the cholinergic anti-inflammatory reflex model. Clinical trials for patients with cardiovascular dysfunction are warranted to assess whether behavioural interventions can contribute independently to the chronic regulation of inflammatory activity and to improved clinical outcomes. |
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Authors:
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Robert P Nolan; John S Floras; Liban Ahmed; Paula J Harvey; Natalie Hiscock; Hilde Hendrickx; Duncan Talbot |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-31 |
Journal Detail:
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Title: Journal of internal medicine Volume: - ISSN: 1365-2796 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 The Association for the Publication of the Journal of Internal Medicine. |
Affiliation:
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University Health Network and University of Toronto, Toronto, Ontario, Canada Women's College Hospital, University of Toronto, Toronto, Canada Unilever Discover, Colworth Science Park, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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