Document Detail

Behaviour profiles in a population of infants later diagnosed as having autistic disorder.
MedLine Citation:
PMID:  15103537     Owner:  NLM     Status:  MEDLINE    
In order to complement findings in the field of early autism and in the context of our studies on the quantitative neurobiological evaluation of patients with autism, we studied a large population of infants later diagnosed as having autistic disorder, using multivariate descriptive statistical methods. The population included 74 infants between six and 35 months, evaluated with the Infant Behavioural Summarised Evaluation (IBSE) scale. Thirteen of the 33 items of the IBSE scale were selected according to previous studies on older patients with autistic disorder. Correspondence analysis was applied to these 13 items, followed by a classical cluster analysis. This procedure permitted the identification of four different profiles which were distinguished on the basis of five main behaviours: activity, auditory perception, sensorimotility, eye contact and use of objects. These profiles are similar to those identified in older children with autism. This study provides an objective description of early clinical markers of the heterogeneity in autism and thus contributes to the description of the onset of autistic disorder. It identified more precise clinical subtyping which will be valuable for future bioclinical studies.
Joëlle Malvy; Catherine Barthélémy; Delphine Damie; Pascal Lenoir; Chrystèle Bodier; Sylvie Roux
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European child & adolescent psychiatry     Volume:  13     ISSN:  1018-8827     ISO Abbreviation:  Eur Child Adolesc Psychiatry     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-22     Completed Date:  2004-08-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9212296     Medline TA:  Eur Child Adolesc Psychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  115-22     Citation Subset:  IM    
Service Universitaire de Pédopsychiatrie, C. H. U Bretonneau, 2 Boulevard Tonnellé, 37044 Tours Cedex, France.
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MeSH Terms
Autistic Disorder / complications,  diagnosis*,  physiopathology
Brain / physiopathology
Child Behavior / psychology*
Child Behavior Disorders / diagnosis*,  physiopathology
Child Psychology
Child, Preschool
Cluster Analysis
Developmental Disabilities / diagnosis*,  physiopathology
Diagnosis, Differential
Statistics, Nonparametric
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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