Document Detail

Behaviour of indicators of exposure and effect after cessation of occupational exposure to lead.
MedLine Citation:
PMID:  7272239     Owner:  NLM     Status:  MEDLINE    
The behaviour of blood lead (PbB) and of some indicators of effect (erythrocyte protoporphyrin IX (EP), delta-aminolaevulinic acid dehydratase activity of erythrocytes (ALAD), and urinary delta-aminolaevulinic acid (ALAU)) were studied in subjects who had ceased working with inorganic lead for at least one year. Relations between these indices and chelatable lead (PbU-EDTA (lead in urine after injection of CaNa2 EDTA 1 g intravenously)), a test that is used to evaluate the lead deposits in the body, were also analysed. As a comparison, a group of subjects currently exposed was studied. In the workers with past exposure the PbB values were significantly lower, at the same PbU-EDTA levels, than those found in subjects at work. The relation between EP and PbU-EDTA shows that, corresponding levels of chelatable lead, the values of the erythrocyte metabolite are identical in the two groups. Considering the EP-PbB relation, however, at the same PbB levels the protoporphyrin values appear distinctly more altered in the subjects with past exposure. Similar results were obtained from a study of the relations between ALAD and PbU-EDTA and between ALAD and PbB. The relation between ALAU and PbU-EDTA, however, shows that, at the same PbU-EDTA levels the urinary metabolic in past-exposed subjects is distinctly lower than in subjects at work, while the relation between ALAU and PbB shows that, for similar blood lead values, the ALAU levels are identical. On the basis of the results obtained it is concluded that in subjects with past exposure, EP and ALAD can be used in establishing the persistence and extent of an "active deposit" of lead in the organism, while PbB is of very limited use.
L Alessio; M R Castoldi; P Odone; I Franchini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of industrial medicine     Volume:  38     ISSN:  0007-1072     ISO Abbreviation:  Br J Ind Med     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370637     Medline TA:  Br J Ind Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  262-7     Citation Subset:  IM    
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MeSH Terms
Aminolevulinic Acid / urine
Environmental Exposure
Erythrocytes / analysis,  drug effects
Lead / adverse effects*,  blood
Occupational Medicine*
Porphobilinogen Synthase / blood
Protoporphyrins / blood
Time Factors
Reg. No./Substance:
0/Protoporphyrins; 106-60-5/Aminolevulinic Acid; 7439-92-1/Lead; EC Synthase

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