Document Detail


The Behaviors of Glutathione and Related Amino Acids in TiO(2) Photocatalytic System.
MedLine Citation:
PMID:  22908992     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Glutathione is a tripeptide capable of diminishing active oxygen species in living cells. The photocatalytic decomposition glutathione and related amino acids in TiO2 suspension was investigated with 1H NMR spectroscopy. The results suggest that both glutathione in reduced and oxidative forms are adsorbed on the TiO2 surface by carboxyl or amino groups but not by the thiol group of the side chain which plays a crucial role in the glutathione cycle, to be degraded. This means that the function of glutathione cycle should be deteriorated in living cells by the adsorption. However, the decomposition rates are considerably slow as compared with those of the constituent amino acids (Glu, Cys, and Gly), possibly reflecting the self-defensive property against active oxygen species.
Authors:
Atsuko Y Nosaka; Goro Tanaka; Yoshio Nosaka
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-21
Journal Detail:
Title:  The journal of physical chemistry. B     Volume:  -     ISSN:  1520-5207     ISO Abbreviation:  J Phys Chem B     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101157530     Medline TA:  J Phys Chem B     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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