| Behaviorally measured audiograms and gap detection thresholds in CBA/CaJ mice. | |
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MedLine Citation:
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PMID: 19756650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tone detection and temporal gap detection thresholds were determined in CBA/CaJ mice using a Go/No-go procedure and the psychophysical method of constant stimuli. In the first experiment, audiograms were constructed for five CBA/CaJ mice. Thresholds were obtained for eight pure tones ranging in frequency from 1 to 42 kHz. Audiograms showed peak sensitivity between 8 and 24 kHz, with higher thresholds at lower and higher frequencies. In the second experiment, thresholds for gap detection in broadband and narrowband noise bursts were measured at several sensation levels. For broadband noise, gap thresholds were between 1 and 2 ms, except at very low sensation levels, where thresholds increased significantly. Gap thresholds also increased significantly for low pass-filtered noise bursts with a cutoff frequency below 18 kHz. Our experiments revised absolute auditory thresholds in the CBA/CaJ mouse strain and demonstrated excellent gap detection ability in the mouse. These results add to the baseline behavioral data from normal-hearing mice which have become increasingly important for assessing auditory abilities in genetically altered mice. |
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Authors:
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Kelly E Radziwon; Kristie M June; Daniel J Stolzberg; Matthew A Xu-Friedman; Richard J Salvi; Micheal L Dent |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology Volume: 195 ISSN: 1432-1351 ISO Abbreviation: J. Comp. Physiol. A Neuroethol. Sens. Neural. Behav. Physiol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2009-10-15 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101141792 Medline TA: J Comp Physiol A Neuroethol Sens Neural Behav Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 961-9 Citation Subset: IM |
Affiliation:
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Department of Psychology, University at BuValo, The State University of New York, BuValo, NY 14260, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Audiometry, Pure-Tone Auditory Threshold* Behavior, Animal* Conditioning, Operant Cues Discrimination (Psychology) Female Male Mice Mice, Inbred CBA Motor Activity* Pattern Recognition, Physiological* Pitch Discrimination* Sound Spectrography Time Perception |
| Grant Support | |
ID/Acronym/Agency:
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DC009483/DC/NIDCD NIH HHS; R03 DC009483-01/DC/NIDCD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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