Document Detail

Behavioral toxicology and risk assessment.
MedLine Citation:
PMID:  2247046     Owner:  NLM     Status:  MEDLINE    
In order to establish safe exposure levels to toxic chemicals, risk assessment guidelines have been developed. These guidelines evaluate epidemiologic and animal research data on a particular chemical, as well as dose-response relationships, animal to human extrapolation and assessment of exposure levels of populations. Using the guidelines, risk characterization is established in order to determine a strategy for reducing undesirable risk to human populations. Using both human neonatal lead exposure data and results from rodent and primate studies, this review examines the possibility that behavioral measurements are sufficient to provide adequate risk assessment guidelines for lead intoxication of the developing organism. The overall trend in these data during the past 10 years has been to show that exposures to inorganic lead at levels previously considered safe have long-lasting significant alterations in behavioral measures, suggesting that central nervous system function has been altered irreversibly. The conclusion is drawn that behavioral toxicology can provide sensitive, quantitative and reliable data for risk assessment and that in the future these methodologies could be used to set exposure guidelines for other neurotoxic chemicals.
Z Annau
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  12     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    1990 Sep-Oct
Date Detail:
Created Date:  1991-01-09     Completed Date:  1991-01-09     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
Johns Hopkins University, Department of Environmental Health Sciences, Baltimore, MD.
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MeSH Terms
Behavior / drug effects*
Behavior, Animal / drug effects*
Intelligence Tests
Lead / toxicity
Lead Poisoning / psychology
Nervous System / drug effects*
Toxicology / methods*
Reg. No./Substance:

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