Document Detail


Behavioral teratogenicity of methamphetamine.
MedLine Citation:
PMID:  1920543     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnant Wistar rats were given daily subcutaneous administrations of methamphetamine (MAPT; varying doses ranging from 1.0 to 4.5 mg/kg) from days 7 to 20 of gestation and teratogenic effects have been determined. The teratogenic effects inducible with orally administered caffeine (90 mg/kg/day) for the same durations were used as the positive controls. MAPT doses greater than 2.0 mg/kg have suppressed the rate of maternal weight gain. Some of the offsprings (F1) of the prenatal MAPT treated groups had decreased growth rate and delayed development of physical characters and functional reflexes. The male offsprings of the MAPT treated groups had significant decreases in their spontaneous motor activity but had enhanced conditioned avoidance responses. However, the mating performances of these offsprings were not affected. These results indicated that prenatal exposure of MAPT may induce some behavioral teratogenicity in rats.
Authors:
D H Cho; H M Lyu; H B Lee; P Y Kim; K Chin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  16 Suppl 1     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-11-20     Completed Date:  1991-11-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  37-49     Citation Subset:  IM    
Affiliation:
Department of Toxicology, National Institute of Safety Research, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Avoidance Learning / drug effects
Behavior, Animal / drug effects*
Body Weight / drug effects
Female
Gestational Age
Growth / drug effects
Male
Methamphetamine / toxicity*
Motor Activity / drug effects
Postural Balance / drug effects
Pregnancy
Rats
Rats, Inbred Strains
Reflex / drug effects
Sexual Behavior, Animal / drug effects
Teratogens*
Chemical
Reg. No./Substance:
0/Teratogens; 537-46-2/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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