Document Detail


Behavioral states may be associated with distinct spatial patterns in electrocorticogram.
MedLine Citation:
PMID:  21464836     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
To determine if behavioral states are associated with unique spatial electrocorticographic (ECoG) patterns, we obtained recordings with a microgrid electrode array applied to the cortical surface of a human subject. The array was constructed with the intent of extracting maximal spatial information by optimizing interelectrode distances. A 34-year-old patient with intractable epilepsy underwent intracranial ECoG monitoring after standard methods failed to reveal localization of seizures. During the 8-day period of invasive recording, in addition to standard clinical electrodes a square 1 × 1 cm microgrid array with 64 electrodes (1.25 mm separation) was placed on the right inferior temporal gyrus. Careful review of video recordings identified four extended naturalistic behaviors: reading, conversing on the telephone, looking at photographs, and face-to-face interactions. ECoG activity recorded with the microgrid that corresponded to these behaviors was collected and ECoG spatial patterns were analyzed. During periods of ECoG selected for analysis, no electrographic seizures or epileptiform patterns were present. Moments of maximal spatial variance are shown to cluster by behavior. Comparisons between conditions using a permutation test reveal significantly different spatial patterns for each behavior. We conclude that ECoG recordings obtained on the cortical surface with optimal high spatial frequency resolution reveal distinct local spatial patterns that reflect different behavioral states, and we predict that similar patterns will be found in many if not most cortical areas on which a microgrid is placed.
Authors:
Heracles Panagiotides; Walter J Freeman; Mark D Holmes; Dimitrios Pantazis
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Publication Detail:
Type:  Journal Article     Date:  2010-11-13
Journal Detail:
Title:  Cognitive neurodynamics     Volume:  5     ISSN:  1871-4099     ISO Abbreviation:  Cogn Neurodyn     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-04-05     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101306907     Medline TA:  Cogn Neurodyn     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-66     Citation Subset:  -    
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