Document Detail

Behavioral specificity of effects of 2-mercaptoacetate on independent ingestion in developing rats.
MedLine Citation:
PMID:  10086228     Owner:  NLM     Status:  MEDLINE    
Blockade of fatty acid oxidation in rat pups using 2-Mercaptoacetate (MA) produces increases in independent ingestion by 12 days of age. In the present experiments, the behavioral specificity of the effects of MA on ingestion were examined. In the first experiment, administration of MA to pups aged 9 and 12 days of age failed to increase intake of an oral infusion of a milk diet. In the second experiment, administration of MA did enhance intake of a milk diet in a short-term test of consuming from the floor of a test container and the level of gastric fill appeared to determine intake during the test. Finally, administration of MA did not affect intake of water in 9- or 12-day-old pups. These results suggest that MA produces increases in intake through specific effects on selective ingestive responses and not through nonspecific behavioral arousal.
S E Swithers; R L Peters; H S Shin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental psychobiology     Volume:  34     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-22     Completed Date:  1999-06-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
Department of Psychological Sciences, Purdue University, West Lafayette, IN 47907-1364, USA.
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MeSH Terms
Arousal / drug effects
Behavior, Animal / drug effects*,  physiology*
Eating / drug effects
Fatty Acids / metabolism
Feeding Behavior / drug effects
Rats, Sprague-Dawley / growth & development
Thioglycolates / pharmacology*
Reg. No./Substance:
0/Fatty Acids; 0/Thioglycolates; 68-11-1/2-mercaptoacetate

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