Document Detail


Behavioral recovery after irreversible inactivation of D-1 and D-2 dopamine receptors.
MedLine Citation:
PMID:  2564615     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Irreversible inactivation of both D-1 and D-2 dopamine (DA) receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) resulted in complete loss of stereotypy response to R-(-)-N-propylnorapomorphine (NPA; 0.1-1.0 mg/kg, s.c.) 24 hr later. Stereotyped sniffing recovered much more rapidly than oral behaviors. The D-2 antagonist sulpiride (200 mg/kg) and the putatively nonselective antagonist cis-flupenthixol (2 mg/kg), administered prior to EEDQ, prevented the loss of NPA-induced sniffing but only partially protected against loss of oral behaviors 24 hr later. Complete protection of both behaviors was seen after pretreatment with a combination of sulpiride and the selective D-1 antagonist SCH 23390 (1 mg/kg); pretreatment with the selective D-1 antagonist SCH 23390 alone, however, did not modify the rate of recovery of either behavioral response. The results suggest that either different populations of DA receptors mediate expression of these behaviors or stimulation of a small fraction of the total DA receptor pool may be sufficient to elicit sniffing but not oral responses. Furthermore, maintaining a normal complement of D-2 rather than D-1 receptors appears to be a critical determinant for the elicitation of these behaviors.
Authors:
E Meller; F Bordi; K Bohmaker
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Life sciences     Volume:  44     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1989  
Date Detail:
Created Date:  1989-05-11     Completed Date:  1989-05-11     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1019-26     Citation Subset:  IM    
Affiliation:
Millhauser Laboratories, Department of Psychiatry, New York University Medical Center, NY 10016.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apomorphine / analogs & derivatives*,  pharmacology
Benzazepines / pharmacology*
Dopamine Agents / pharmacology*
Dopamine Antagonists
Flupenthixol / pharmacology*
Male
Quinolines / pharmacology*
Rats
Rats, Inbred Strains
Receptors, Dopamine / drug effects,  physiology*
Receptors, Dopamine D1
Receptors, Dopamine D2
Reference Values
Stereotyped Behavior / drug effects*
Sulpiride / pharmacology*
Thioxanthenes / pharmacology*
Grant Support
ID/Acronym/Agency:
MH-35976/MH/NIMH NIH HHS; NS-22589/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Benzazepines; 0/Dopamine Agents; 0/Dopamine Antagonists; 0/Quinolines; 0/Receptors, Dopamine; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 0/Thioxanthenes; 15676-16-1/Sulpiride; 16357-59-8/EEDQ; 2709-56-0/Flupenthixol; 58-00-4/Apomorphine; 58479-52-0/N-n-propylnorapomorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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