| Behavioral recovery after irreversible inactivation of D-1 and D-2 dopamine receptors. | |
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MedLine Citation:
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PMID: 2564615 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Irreversible inactivation of both D-1 and D-2 dopamine (DA) receptors by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) resulted in complete loss of stereotypy response to R-(-)-N-propylnorapomorphine (NPA; 0.1-1.0 mg/kg, s.c.) 24 hr later. Stereotyped sniffing recovered much more rapidly than oral behaviors. The D-2 antagonist sulpiride (200 mg/kg) and the putatively nonselective antagonist cis-flupenthixol (2 mg/kg), administered prior to EEDQ, prevented the loss of NPA-induced sniffing but only partially protected against loss of oral behaviors 24 hr later. Complete protection of both behaviors was seen after pretreatment with a combination of sulpiride and the selective D-1 antagonist SCH 23390 (1 mg/kg); pretreatment with the selective D-1 antagonist SCH 23390 alone, however, did not modify the rate of recovery of either behavioral response. The results suggest that either different populations of DA receptors mediate expression of these behaviors or stimulation of a small fraction of the total DA receptor pool may be sufficient to elicit sniffing but not oral responses. Furthermore, maintaining a normal complement of D-2 rather than D-1 receptors appears to be a critical determinant for the elicitation of these behaviors. |
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Authors:
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E Meller; F Bordi; K Bohmaker |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Life sciences Volume: 44 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1989 |
Date Detail:
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Created Date: 1989-05-11 Completed Date: 1989-05-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1019-26 Citation Subset: IM |
Affiliation:
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Millhauser Laboratories, Department of Psychiatry, New York University Medical Center, NY 10016. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apomorphine / analogs & derivatives*, pharmacology Benzazepines / pharmacology* Dopamine Agents / pharmacology* Dopamine Antagonists Flupenthixol / pharmacology* Male Quinolines / pharmacology* Rats Rats, Inbred Strains Receptors, Dopamine / drug effects, physiology* Receptors, Dopamine D1 Receptors, Dopamine D2 Reference Values Stereotyped Behavior / drug effects* Sulpiride / pharmacology* Thioxanthenes / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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MH-35976/MH/NIMH NIH HHS; NS-22589/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzazepines; 0/Dopamine Agents; 0/Dopamine Antagonists; 0/Quinolines; 0/Receptors, Dopamine; 0/Receptors, Dopamine D1; 0/Receptors, Dopamine D2; 0/Thioxanthenes; 15676-16-1/Sulpiride; 16357-59-8/EEDQ; 2709-56-0/Flupenthixol; 58-00-4/Apomorphine; 58479-52-0/N-n-propylnorapomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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