| Behavioral and pharmacological effects of centrally administered aminooxyacetic acid in rats. | |
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MedLine Citation:
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PMID: 1385183 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present experiment unilateral intrastriatal injections of aminooxyacetic acid (1, 2.5, 5 mumol) to freely moving animals and pentobarbital-anesthetized rats produced contralateral jerks and dose-dependent mortality, but no barrel rotation. At 10-12 days there were no significant differences in exploratory activity, passive avoidance behavior, and elevated plus-maze test in aminooxyacetic acid-treated animals as compared with controls. However freely moving animals microinjected with aminooxyacetic acid (but not the pentobarbital-pretreated group) had impaired learning activity in an active avoidance conditioning test, and showed reduced striatal concentrations of substance P and GABA. Intrastriatal injections of aminooxyacetic acid therefore result in both acute and chronic behavioral changes which are attenuated by pentobarbital anesthesia. |
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Authors:
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L Vécsei; M F Beal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 220 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-12-01 Completed Date: 1992-12-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 259-62 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Medical School of Pécs, Hungary. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminooxyacetic Acid
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administration & dosage,
pharmacology* Animals Avoidance Learning / drug effects Behavior, Animal / drug effects* Corpus Striatum / drug effects*, metabolism Dose-Response Relationship, Drug Male Rats Rats, Sprague-Dawley Substance P / metabolism* gamma-Aminobutyric Acid / metabolism* |
| Chemical | |
Reg. No./Substance:
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33507-63-0/Substance P; 56-12-2/gamma-Aminobutyric Acid; 645-88-5/Aminooxyacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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