| Behavioral measures in animal studies: relevance to patients with epilepsy. | |
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MedLine Citation:
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PMID: 18166501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relevance of behavioral endpoints in animal seizure models to clinical epilepsy is outlined and enhanced in the present review by linking specific preclinical dependent measures with a quality-of-life scale that serves as an index of the health and welfare of patients with epilepsy (Quality of Life in Epilepsy inventory). This preclinical-to-clinical translation is possible based on existing literature within at least three behavioral domains: (1) physical and motor actions, (2) affective and emotional responses to environmental challenge, and (3) social, sexual, and parental functions. Face valid commonalities in observable behaviors are emphasized with the goal of engaging basic and applied researchers in collaborative research projects to accelerate the pace of discovery in the behavioral phenotyping of epilepsy field. |
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Authors:
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Stephen C Heinrichs; Edward B Bromfield |
Publication Detail:
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Type: Journal Article; Review Date: 2007-12-31 |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 12 ISSN: 1525-5050 ISO Abbreviation: Epilepsy Behav Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-03-24 Completed Date: 2008-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 612-21 Citation Subset: IM |
Affiliation:
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VA Medical Center, Research 151-Neuropharmacology, 150 South Huntington Avenue, Boston, MA 02130, USA. stephen.heinrichs@va.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Affective Symptoms
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complications,
physiopathology,
psychology* Animals Behavior, Animal Disease Models, Animal* Epilepsy / complications, physiopathology, psychology* Humans Quality of Life / psychology* Rats Reproducibility of Results |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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