Document Detail


Behavioral and immunological consequences of brief mother-infant separation: a species comparison.
MedLine Citation:
PMID:  2379762     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The immediate behavioral and immunological consequences of a single 2-week maternal separation experience were studied in socially housed 7-month old bonnet and pigtail macaques. Maternal separation was associated with species dependent behavioral changes. Both species showed significant increases in ingestive behaviors associated with separation. Separated and matched controls showed an increase in disturbance behaviors (vocalization, startles, shaking, temper-tantrums) that subsided after 24-36 hours in control subjects, but continued, albeit with species-dependent patterns, in the separated monkeys. Allomaternal care of the separated bonnet infants but not the pigtail infants was associated with a progressive reduction of these disturbance behaviors during the separation period. Following a period of agitation, pigtail infants showed a depressive phase characterized by slouched, withdrawn postures and reduced motor activity. As a group, the separated infants of both species were not different from controls with respect to lymphocyte activation by mitogens, a measure of immunocompetence. However, when individual behavioral responses were considered, the change in lymphocyte activation during separation was significantly related to behavioral responses which reflected disturbance, such that the change in lymphocyte activation following in vitro stimulation with the mitogens phytohemagglutinin and Concanavalin A (markers of the immunocompetence of T lymphocytes) was related to levels of vocalization and time spent in slouched postures. The activation of B lymphocytes by pokeweed mitogen was not influenced by the separation experience nor was it associated with specific behavioral responses to separation. The importance of assessing the affective consequences of stressor is discussed.
Authors:
M L Laudenslager; P E Held; M L Boccia; M L Reite; J J Cohen
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Developmental psychobiology     Volume:  23     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-09-12     Completed Date:  1990-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-64     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80204.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arousal / physiology*
Behavior, Animal / physiology
Female
Immune Tolerance / immunology
Lymphocyte Activation / immunology*
Macaca nemestrina
Macaca radiata
Male
Maternal Deprivation*
Social Environment
Species Specificity*
T-Lymphocytes / immunology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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