Document Detail


Behavioral, hormonal and histological stress markers of anxiety-separation in postnatal rats are reduced by prepro-thyrotropin-releasing hormone 178-199.
MedLine Citation:
PMID:  11872263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated in the present study whether systemic injections of prepro-thyrotropin-releasing-hormone 178-199 (PPTRH 178-199) in postnatal 3-days old rat pups can provide ameliorative effects in a model of anxiety-separation disorder. The pups were individually separated from their mother and placed in a novel environment. PPTRH 178-199-treated animals started exploring the novel environment in a significantly shorter time and elicited significantly less distress vocalizations than control animals. PPTRH 178-199-treated animals also had markedly lower serum adrenocorticotropic hormone and corticosterone compared to control animals. Furthermore, we observed a significant increase in PPTRH 178-199 immunoreactive cell bodies in the hypothalamus of PPTRH 178-199-treated animals compared to controls, suggesting that the peptide crossed the blood-brain barrier. PPTRH 178-199 treatment can help to reduce behavioral and hormonal disturbances associated with anxiety-separation situations.
Authors:
Christine E Stahl; Eva Redei; Yun Wang; Cesario V Borlongan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  321     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-01     Completed Date:  2002-05-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenocorticotropic Hormone / blood
Animals
Animals, Newborn
Anxiety, Separation / drug therapy*,  metabolism,  physiopathology
Behavior, Animal / drug effects*,  physiology
Corticosterone / blood
Disease Models, Animal
Exploratory Behavior / drug effects,  physiology
Hormones / blood
Immunohistochemistry
Maternal Deprivation*
Neurons / drug effects*,  metabolism
Paraventricular Hypothalamic Nucleus / drug effects*,  metabolism
Peptide Fragments / pharmacology*
Protein Precursors / pharmacology*
Rats
Rats, Sprague-Dawley
Stress, Psychological / drug therapy*,  metabolism,  physiopathology
Thyrotropin-Releasing Hormone / pharmacology*
Vocalization, Animal / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Hormones; 0/Peptide Fragments; 0/Protein Precursors; 122018-92-2/prepro-thyrotropin-releasing hormone (178-199); 24305-27-9/Thyrotropin-Releasing Hormone; 50-22-6/Corticosterone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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