| Behavioral evidence for dopaminergic supersensitivity following chronic treatment with methadone or chlorpromazine in the guinea pig. | |
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MedLine Citation:
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PMID: 826925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study demonstrated the enhancement, as a consequence of prior chronic drug treatment, of two behaviors (stereotyped oral behaviors and open field locomoation) which are thought to depend primarily on the striatel dopamine system. Following a 5-week treatment with methadone (MD), chlorpromazine (CPZ), or saline, the dopamine agonist methamphetamine (MA) elicited more intense stereotypies in the MD and CPZ animals. After chronic treatment with MD, the MA-elicited stereotypies were reduced by an acute dose of MD. Stereotyped oral behaviors elicited by a stressful stimulus (foot shock) were enhanced in the MD animals both during and following chronic drug treatment. MA-elicited open field locomotion, measured 2 weeks following termination of chronic drug treatment, was enhanced in the MD and CPZ animals. |
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Authors:
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R D Eibergen; K R Carlson |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Psychopharmacology Volume: 48 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1976 Jul |
Date Detail:
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Created Date: 1977-02-24 Completed Date: 1977-02-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 139-46 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects* Chlorpromazine / pharmacology* Corpus Striatum / metabolism Dopamine / metabolism* Drug Synergism Electroshock Guinea Pigs Humans Male Methadone / pharmacology* Methamphetamine / pharmacology Motor Activity / drug effects Stereotyped Behavior / drug effects |
| Chemical | |
Reg. No./Substance:
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50-53-3/Chlorpromazine; 537-46-2/Methamphetamine; 76-99-3/Methadone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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