| Behavioral evidence for cholecystokinin-opiate interactions in neonatal rats. | |
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MedLine Citation:
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PMID: 3202224 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In adult mammals, cholecystokinin (CCK)-opiate interactions are complex and task dependent. Specifically, CCK antagonizes opiate effects in some cases, yet acts similarly to opiate agonists in others. The present study used behavioral measures to determine how CCK interacts with opiates in neonatal rats. CCK, at doses of 1 microgram/kg and higher, markedly reduced isolation-induced distress vocalization in rat pups. Moreover, CCK selectively prevented naltrexone antagonism of opiate-mediated reduction in distress vocalization in 3- and 11-day-old rats. Yet CCK did not affect opiate-induced analgesia, as measured by the hot-plate paw-lift response. Thus CCK either did not interact with opiates or did so agonistically, with the same (low) dose range, and within subjects. These findings suggest independence of stress and pain systems in neonatal rats and demonstrate a functional interaction between CCK and opioid systems. |
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Authors:
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A Weller; E M Blass |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 255 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1988 Dec |
Date Detail:
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Created Date: 1989-01-26 Completed Date: 1989-01-26 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R901-7 Citation Subset: IM |
Affiliation:
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Department of Psychology, Johns Hopkins University, Baltimore, Maryland 21218. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Cholecystokinin / pharmacology* Drug Interactions Morphine / pharmacology* Motor Activity / drug effects Naltrexone / pharmacology* Pain / physiopathology Rats Rats, Inbred Strains Reference Values Sincalide / pharmacology* Stress, Psychological Vocalization, Animal |
| Grant Support | |
ID/Acronym/Agency:
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DK-18560/DK/NIDDK NIH HHS; MH-00524/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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16590-41-3/Naltrexone; 25126-32-3/Sincalide; 57-27-2/Morphine; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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