Document Detail

Behavioral evaluation of male and female mice pups exposed to fluoxetine during pregnancy and lactation.
MedLine Citation:
PMID:  17519559     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Fluoxetine (FLX) has been widely prescribed for depression during pregnancy and/or lactation. Since serotonin is a neurotrophic factor, the use of FLX by mothers could disrupt brain development resulting in behavioral alterations in their progeny. This study evaluated the effects of developmental FLX exposure on anxiety, depression, aggressivity and pain sensitivity of male and female mice pups. METHODS: Swiss dams were treated daily, by gavage, with 7.5 mg/kg of FLX during pregnancy and lactation. Pups were submitted to open-field, forced swimming, elevated plus-maze, intruder-resident and hot plate tests at adolescence and adulthood. RESULTS AND CONCLUSION: In male pups, exposure to FLX decreased ambulation at postnatal day (PND) 40 and tended (p=0.07) to increase the latency to the first attack in the intruder-resident test at PND 70, suggesting decreased impulsivity. In female pups, FLX exposure increased immobility time in the forced swimming test at both PND 30 and 70, which is interpreted as depressive-like behavior. In conclusion, our results suggest that maternal exposure to FLX during pregnancy and lactation results in enduring behavioral alterations in male and female pups throughout life.
Sabrina F S Lisboa; Paulo E Oliveira; Leandro C Costa; Emerson J Venâncio; Estefânia G Moreira
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Publication Detail:
Type:  Journal Article     Date:  2007-05-23
Journal Detail:
Title:  Pharmacology     Volume:  80     ISSN:  0031-7012     ISO Abbreviation:  Pharmacology     Publication Date:  2007  
Date Detail:
Created Date:  2007-06-28     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  49-56     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2007 S. Karger AG, Basel.
Department of Physiological Sciences, State University of Londrina, Londrina, Brazil.
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MeSH Terms
Analysis of Variance
Antidepressive Agents, Second-Generation / toxicity*
Behavior, Animal / drug effects*
Fluoxetine / toxicity*
Motor Activity / drug effects*
Prenatal Exposure Delayed Effects*
Somatosensory Disorders
Reg. No./Substance:
0/Antidepressive Agents, Second-Generation; 54910-89-3/Fluoxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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