| Behavioral evaluation of hemiparkinsonian MPTP monkeys following dopamine pharmacological manipulation and adrenal co-graft transplantation. | |
| | |
MedLine Citation:
|
PMID: 11144958 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Bradykinesia and rigidity are the symptoms that most directly correlate with loss of striatal dopamine in Parkinson's disease. In the hemiparkinsonian (HP) monkey, this is represented by paucity of movement as measured by coli puterized movement analysis, diminished manual dexterity on clinical examination, and diminished performance on operant behavioral tasks. The present study used an MPTP-induced HP model in rhesus monkeys to evaluate the effectiveness of adrenal medullary and peripheral nerve co-grafts in diminishing parkinsonian symptoms. Unoperated controls (N = 4), surgical controls with caudate lesioning (N = 4), and caudate co-grafted (N = 4) HP monkeys demonstrated diminished movement in the home cage following MPTP. This behavior persisted in unoperated controls, but improved in both surgical control and co-grafted monkeys. Functional hand dexterity evaluations demonstrated similar impairment in all three groups but only surgical controls and co-grafted monkeys demonstrated improvement. In general, rotational behavior in response to apomorphine was consistent with recovery of function in surgical controls and co grafted monkeys, but marked between-subject variability precluded group statistical analyses. None of the monkeys could perform the operant task using the affected limb following MPTP. However, the performance of two co-grafted animals demonstrated partial recovery. L-dopa improved operant performance, demonstrating a dopaminergic component to the task. The results demonstrate recovery of behavioral function after surgical treatment, with adrenal co-grafted monkeys showing the greatest degree of improvement. |
| | |
Authors:
|
L L Howel; L D Byrd; A M McDonough; P M Iuvone; R A Bakay |
Related Documents
:
|
15813198 - Perception of place-of-articulation information in natural speech by monkeys versus hum... 1731038 - Chronic marijuana smoke exposure in the rhesus monkey. ii: effects on progressive ratio... 16435968 - Prospective memory in the formation of learning sets by rhesus monkeys (macaca mulatta). 15240978 - Footfall patterns, stride length and speed of vertical climbing in spider monkeys (atel... 11922118 - A matching advantage for dynamic human faces. 16815788 - Error consistency and the evaluation of treatment outcomes. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Cell transplantation Volume: 9 ISSN: 0963-6897 ISO Abbreviation: Cell Transplant Publication Date: 2000 Sep-Oct |
Date Detail:
|
Created Date: 2000-12-28 Completed Date: 2001-03-29 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9208854 Medline TA: Cell Transplant Country: United States |
Other Details:
|
Languages: eng Pagination: 609-22 Citation Subset: IM |
Affiliation:
|
Yerkes Regional Primate Research Center and Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA. leonard@rmy.emory.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine* 3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid Adrenal Medulla / transplantation* Animals Behavior, Animal / drug effects* Conditioning, Operant Dopamine Agents* Homovanillic Acid / cerebrospinal fluid Hydroxyindoleacetic Acid / cerebrospinal fluid Levodopa / metabolism Macaca mulatta Motor Activity / drug effects Parkinson Disease / metabolism, surgery* Parkinson Disease, Secondary / chemically induced Sural Nerve / transplantation* Tyrosine 3-Monooxygenase / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
NS24340/NS/NINDS NIH HHS; RR00165/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Dopamine Agents; 0/Levodopa; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Technique for bilateral intracranial implantation of cells in monkeys using an automated delivery sy...
Next Document: Neurotrophic factors NGF and FGF-2 alter levels of huntingtin (IT15) in striatal neuronal cell cultu...