Document Detail


Behavioral evaluation of hemiparkinsonian MPTP monkeys following dopamine pharmacological manipulation and adrenal co-graft transplantation.
MedLine Citation:
PMID:  11144958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bradykinesia and rigidity are the symptoms that most directly correlate with loss of striatal dopamine in Parkinson's disease. In the hemiparkinsonian (HP) monkey, this is represented by paucity of movement as measured by coli puterized movement analysis, diminished manual dexterity on clinical examination, and diminished performance on operant behavioral tasks. The present study used an MPTP-induced HP model in rhesus monkeys to evaluate the effectiveness of adrenal medullary and peripheral nerve co-grafts in diminishing parkinsonian symptoms. Unoperated controls (N = 4), surgical controls with caudate lesioning (N = 4), and caudate co-grafted (N = 4) HP monkeys demonstrated diminished movement in the home cage following MPTP. This behavior persisted in unoperated controls, but improved in both surgical control and co-grafted monkeys. Functional hand dexterity evaluations demonstrated similar impairment in all three groups but only surgical controls and co-grafted monkeys demonstrated improvement. In general, rotational behavior in response to apomorphine was consistent with recovery of function in surgical controls and co grafted monkeys, but marked between-subject variability precluded group statistical analyses. None of the monkeys could perform the operant task using the affected limb following MPTP. However, the performance of two co-grafted animals demonstrated partial recovery. L-dopa improved operant performance, demonstrating a dopaminergic component to the task. The results demonstrate recovery of behavioral function after surgical treatment, with adrenal co-grafted monkeys showing the greatest degree of improvement.
Authors:
L L Howel; L D Byrd; A M McDonough; P M Iuvone; R A Bakay
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cell transplantation     Volume:  9     ISSN:  0963-6897     ISO Abbreviation:  Cell Transplant     Publication Date:    2000 Sep-Oct
Date Detail:
Created Date:  2000-12-28     Completed Date:  2001-03-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9208854     Medline TA:  Cell Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  609-22     Citation Subset:  IM    
Affiliation:
Yerkes Regional Primate Research Center and Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA. leonard@rmy.emory.edu
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine*
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid
Adrenal Medulla / transplantation*
Animals
Behavior, Animal / drug effects*
Conditioning, Operant
Dopamine Agents*
Homovanillic Acid / cerebrospinal fluid
Hydroxyindoleacetic Acid / cerebrospinal fluid
Levodopa / metabolism
Macaca mulatta
Motor Activity / drug effects
Parkinson Disease / metabolism,  surgery*
Parkinson Disease, Secondary / chemically induced
Sural Nerve / transplantation*
Tyrosine 3-Monooxygenase / metabolism
Grant Support
ID/Acronym/Agency:
NS24340/NS/NINDS NIH HHS; RR00165/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Dopamine Agents; 0/Levodopa; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; EC 1.14.16.2/Tyrosine 3-Monooxygenase

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