| Behavioral and electrocortical effects of tolonidine in rats. | |
| | |
MedLine Citation:
|
PMID: 3797809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The rats systemic administration of tolonidine in rats (0.05-5.0 mumol/Kg) produced behavioural and electrocortical slow-wave sleep lasting between 35 and 200 min depending on the dose. In addition, a dose-dependent fall in deep body temperature was observed. Similar effects were evoked by infusing tolonidine (5-80 nmol) into the third cerebral ventricle. Behavioural, ECoG and body temperature effects were prevented by previous intraventricular or systemic injection of phentolamine, an antagonist at alpha 1- and alpha 2-adrenoceptors, and of yohimbine, an antagonist at alpha 2-adrenoceptors, whereas prazosin, an alpha 1-adrenoceptor antagonist, was ineffective. In conclusion, the present experiments show that tolonidine possesses central effects similar to those evoked by clonidine and provide further evidence in favour of the idea that central alpha 2-adrenoceptors are involved in the control of slow-wave sleep and body temperature. |
| | |
Authors:
|
G B De Sarro; C Ascioti; G Fersini; V Libri; E Marmo; G Nisticò |
Related Documents
:
|
935209 - Is the release of noradrenaline necessary for self-stimulation of the brain? 23108119 - Prevention of barrett esophagus and esophageal adenocarcinoma by smoothened inhibitor i... 22451119 - Effect of boswellia serrata on antioxidant status in an experimental model of colitis r... 22840449 - Preliminary study on antifertility activity of enicostemma axillare leaves and urena lo... 1356149 - Functional subsensitivity of 5-hydroxytryptamine1c or alpha 2 adrenergic heteroreceptor... 8190709 - Chronic l-alpha-glyceryl-phosphoryl-choline increases inositol phosphate formation in b... 15196919 - Study of cytokine induced neuropathology by high resolution proton nmr spectroscopy of ... 3996509 - Parathyroidectomy-pinealectomy-induced seizures: effects of intersurgical length. 21630299 - Blood oxidative stress in taiwan workers exposed to carbon disulfide. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Research communications in chemical pathology and pharmacology Volume: 54 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1986 Dec |
Date Detail:
|
Created Date: 1987-02-12 Completed Date: 1987-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 299-312 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal / drug effects Body Temperature / drug effects Clonidine / analogs & derivatives*, antagonists & inhibitors, pharmacology Injections, Intraperitoneal Injections, Intraventricular Male Phentolamine / pharmacology Rats Sleep / drug effects Yohimbine / pharmacology |
| Chemical | |
Reg. No./Substance:
|
146-48-5/Yohimbine; 4201-22-3/tolonidine; 4205-90-7/Clonidine; 50-60-2/Phentolamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Meperidine disposition in burn patients.
Next Document: Effects of hydralazine on adrenal and cardiac sympathetic nerve activity in anesthetized rats.