Document Detail

Behavioral effects of trichloroethylene and tetrachloroethylene in mice.
MedLine Citation:
PMID:  9329056     Owner:  NLM     Status:  MEDLINE    
This study was performed to clarify the toxicological profiles of trichloroethylene (TRCE) and tetrachloroethylene (TECE) when they are administered intraperitoneally in mice. The ED50 for loss of righting reflex were 2596 mg/kg in TRCE and 4209 mg/kg in TECE. TRCE and TECE impaired bridge test performance at 500 and 2000 mg/kg, respectively. An operant behavior performance was also inhibited by TRCE at 1000 mg/kg and by TECE at 2000 mg/kg. Both TRCE and TECE exhibited anticonflict effects in a Vogel-type task at 500 mg/kg. This effect was confirmed by the finding that TRCE exhibited anticonflict action in a Geller-type paradigm at 250 mg/kg and more, as did TRCE did at 1000 mg/kg. These results show that TRCE and TECE affect various behaviors in mice and suggest that conflict behaviors are one of the most sensitive behavioral indicators of the effects of these substances. The toxicological profiles of TRCE and TECE with respect to behavioral effects were very similar, and they can be classified in a single category.
T Umezu; J Yonemoto; Y Soma; T Miura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  58     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-06     Completed Date:  1998-02-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  665-71     Citation Subset:  IM    
Regional Enviroment Division, National Institute for Environmental Studies, Ibaraki, Japan.
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MeSH Terms
Behavior, Animal / drug effects*
Conditioning, Operant / drug effects
Conflict (Psychology)
Dose-Response Relationship, Drug
Injections, Intraperitoneal
Mice, Inbred ICR
Postural Balance / drug effects
Reflex / drug effects
Solvents / administration & dosage,  toxicity*
Tetrachloroethylene / administration & dosage,  toxicity*
Trichloroethylene / administration & dosage,  toxicity*
Reg. No./Substance:
0/Solvents; 127-18-4/Tetrachloroethylene; 79-01-6/Trichloroethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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