Document Detail


Behavioral effects on rats of high strength magnetic fields generated by a resistive electromagnet.
MedLine Citation:
PMID:  16176822     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been reported previously that exposure to static high magnetic fields of 7 T or above in superconducting magnets has behavioral effects on rats. In particular, magnetic field exposure acutely but transiently suppressed rearing and induced walking in tight circles; the direction of circular locomotion was dependent on the rats' orientation within the magnet. Furthermore, when magnet exposure was paired with consumption of a palatable, novel solution, rats acquired a persistent taste aversion. In order to confirm these results under more controlled conditions, we exposed rats to static magnetic fields of 4 to 19.4 T in a 189 mm bore, 20 T resistive magnet. By using a resistive magnet, field strengths could be arbitrary varied from -19.4 to 19.4 T within the same bore. Rearing was suppressed after exposure to 4 T and above; circling was observed after 7 T and above. Conditioned taste aversion was acquired after 14 T and above. The effects of the magnetic fields were dependent on orientation. Exposure to +14 T induced counter-clockwise circling, while exposure to -14 T induced clockwise circling. Exposure with the rostral-caudal axis of the rat perpendicular to the magnetic field produced an attenuated behavioral response compared to exposure with the rostral-caudal axis parallel to the field. These results in a single resistive magnet confirm and extend our earlier findings using multiple superconducting magnets. They demonstrate that the behavioral effects of exposure within large magnets are dependent on the magnetic field, and not on non-magnetic properties of the machinery. Finally, the effects of exposure to 4 T are clinically relevant, as 4 T magnetic fields are commonly used in functional MRI assays.
Authors:
Thomas A Houpt; David W Pittman; Christina Riccardi; Jennifer A Cassell; Denesa R Lockwood; Jan M Barranco; Bumsup Kwon; James C Smith
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-09-19
Journal Detail:
Title:  Physiology & behavior     Volume:  86     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-24     Completed Date:  2006-02-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  379-89     Citation Subset:  IM    
Affiliation:
Department of Biological Science, The Florida State University, Tallahassee, FL 32306-4340, USA. houpt@neuro.fsu.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Avoidance Learning / radiation effects
Behavior, Animal / radiation effects*
Conditioning (Psychology) / radiation effects
Dose-Response Relationship, Radiation
Electromagnetic Fields*
Electromagnetic Phenomena / instrumentation,  methods*
Male
Motor Activity / radiation effects
Rats
Rats, Sprague-Dawley
Taste / radiation effects
Time Factors
Grant Support
ID/Acronym/Agency:
DC 04607/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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