Document Detail

Behavioral effects of original tetrapeptide, an analog of N-terminal nociceptin fragment.
MedLine Citation:
PMID:  22816077     Owner:  NLM     Status:  In-Data-Review    
The study examined the effect of an analog to N-terminal nociceptin fragment AcOH×Phe-Gly-Gly-Phe-NH(2) on the behavior of albino rats. This tetrapeptide (5 μg/kg intraperitoneally) significantly enhanced motor and exploratory activity in mature rats and in 42-day pups and produced opposite effects in 21-day rat pups, which attests to the complex dynamics of maturation of nervous structures involved in the realization of nociceptin action.
E A Ivanova; N Yu Sarycheva; V A Dubynin; A V Malyshev; V N Kalikhevich; Z A Ardemasova; A A Kamensky
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  153     ISSN:  1573-8221     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng; rus     Pagination:  177-81     Citation Subset:  IM    
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University; Department of Natural Substance Chemistry, Chemistry Faculty, St. Petersburg State University, Russia.
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