Document Detail


Behavioral effects of amphetamine in streptozotocin-treated rats.
MedLine Citation:
PMID:  18155695     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Experimentally-induced diabetes can modify the behavioral and neurochemical effects of drugs acting on dopamine systems, possibly through insulin-related regulation of dopamine transporter activity. In this study, several behavioral procedures were used to examine possible changes in sensitivity to amphetamine and other drugs in rats rendered diabetic by a single injection of streptozotocin. Conditioned place preference developed to food (Froot Loops) in both control and diabetic rats, demonstrating that conditioned place preference with tactile stimuli can occur in streptozotocin-treated rats. Baseline locomotion was lower in streptozotocin-treated as compared to control rats, although amphetamine significantly increased locomotion in all rats. Conditioned place preference developed to amphetamine regardless of whether rats had received streptozotocin or saline. A second study compared the potency of drugs to decrease lever pressing maintained by food, before and after streptozotocin treatment. Gamma-hydroxybutyrate and amphetamine were less potent after streptozotocin while the potency of raclopride, quinpirole, ketamine, haloperidol and cocaine was not significantly changed by streptozotocin. While markedly affecting locomotion, body weight and blood glucose, streptozotocin only modestly affected sensitivity to the behavioral effects of amphetamine and other drugs; these results fail to confirm previous reports of decreased behavioral actions of stimulants in diabetic rats.
Authors:
Rajkumar J Sevak; Wouter Koek; Lynette C Daws; William Anthony Owens; Aurelio Galli; Charles P France
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-11-28
Journal Detail:
Title:  European journal of pharmacology     Volume:  581     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-05-23     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  105-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amphetamine / pharmacology*
Animals
Behavior, Animal / drug effects*
Blood Glucose / analysis
Body Weight
Conditioning (Psychology) / drug effects
Diabetes Mellitus, Experimental / psychology*
Dopamine / physiology
Dopamine Plasma Membrane Transport Proteins / physiology
Male
Motor Activity / drug effects
Rats
Rats, Sprague-Dawley
Streptozocin
Grant Support
ID/Acronym/Agency:
DA14684/DA/NIDA NIH HHS; DA17918/DA/NIDA NIH HHS; K05 DA017918/DA/NIDA NIH HHS; K05 DA017918-04/DA/NIDA NIH HHS; R01 DA014684/DA/NIDA NIH HHS; R01 DA014684-04/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Dopamine Plasma Membrane Transport Proteins; 5W494URQ81/Streptozocin; CK833KGX7E/Amphetamine; VTD58H1Z2X/Dopamine
Comments/Corrections

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