Document Detail

Behavioral effects of Org 2766, a synthetic analog of the adrenocorticotrophic hormone (4-9), in 14 outpatient autistic children.
MedLine Citation:
PMID:  2177746     Owner:  NLM     Status:  MEDLINE    
Fourteen children (12 infantile autism full syndrome present, 2 atypical pervasive developmental disorder) between 5 and 13 years of age participated in a double-blind placebo-controlled cross-over trial. Each child received 20 mg Org 2766 (synthetic analog of ACTH 4-9)/day during 4 weeks, or placebo in a randomly assigned sequence. Drug effects were monitored by ethological playroom observation and by Aberrant Behavior Checklist ratings by parents and teachers. Data of the playroom observation pointed to an activating influence of Org 2766, as revealed by a significant decrease of stereotypic behavior and significant increases in "change toys," "locomote," and "talk." Checklist ratings did not show significant changes. The clinical implications of these findings are discussed.
J K Buitelaar; H van Engeland; J M van Ree; D de Wied
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  20     ISSN:  0162-3257     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-03-08     Completed Date:  1991-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  467-78     Citation Subset:  IM    
Department of Child and Adolescent Psychiatry, State University Hospital of Utrecht, The Netherlands.
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MeSH Terms
Adrenocorticotropic Hormone / analogs & derivatives*,  therapeutic use
Attention / drug effects
Autistic Disorder / drug therapy*,  psychology
Child Development Disorders, Pervasive / drug therapy*,  psychology
Double-Blind Method
Motor Activity / drug effects
Peptide Fragments / therapeutic use*
Single-Blind Method
Social Environment
Stereotyped Behavior / drug effects
Reg. No./Substance:
0/Anticonvulsants; 0/Peptide Fragments; 50913-82-1/Org 2766; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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