Document Detail

Behavioral dimensions and acetylcholinesterase inhibitor-related effect in Alzheimer disease over time: a latent trajectory modeling.
MedLine Citation:
PMID:  19996874     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate whether treatment with acetylcholinesterase inhibitors (AChEIs) exerts a favorable effect on the behavioral dimensions in Alzheimer disease (AD) over time. METHODS: Two hundred AD patients entered the study and underwent clinical and neuropsychologic examination. Neuropsychiatry Inventory (NPI) total scores and 4 behavioral factor scores, termed "psychosis," "moods," "apathy," and "frontal" were also evaluated. Of this large sample, 107 completed the 6-month follow-up and 83 were followed through for 1 year. Latent Trajectory Modeling analysis was applied, which allows for the estimation of a developmental trajectory over time for each case in the sample adjusting for confounders. These trajectories can be modeled to better understand individual differences in rates of change of behavioral dimensions and the relationship with AChEIs dose therapy. RESULTS: The behavioral phenotypes and NPI total scores were differently expressed, the most prevalent being the mood and the less prevalent being frontal endophenotype over time. The development relationship between the baseline and trend levels of behavioral phenotypes, or NPI total scores and the differences of AChEIs, adjusting for disease severity, concurrent drugs, and demographic data did not "travel together" through time, that is, the correlations of individual trajectories could be estimated equal to zeros. CONCLUSIONS: These data confirm that behavioral dimensions are variably represented in AD and change over time. However, AChEIs could not influence the behavioral disturbance pattern, both measured as total behavioral abnormality burden or as behavioral defined clusters.
Barbara Borroni; Mario Grassi; Chiara Costanzi; Marta Bianchi; Alessandro Padovani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology     Volume:  22     ISSN:  1543-3641     ISO Abbreviation:  Cogn Behav Neurol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167278     Medline TA:  Cogn Behav Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  222-8     Citation Subset:  IM    
Department of Neurology, Center for Aging Brain and Dementia, University of Brescia, Italy.
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MeSH Terms
Affect / drug effects*
Alzheimer Disease / drug therapy*,  psychology*
Cholinesterase Inhibitors / therapeutic use*
Longitudinal Studies
Models, Neurological
Neuropsychological Tests
Patient Selection
Prospective Studies
Severity of Illness Index
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Cholinesterase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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