| Behavioral deficit and decreased GABA receptor functional regulation in the cerebellum of epileptic rats: effect of Bacopa monnieri and bacoside A. | |
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MedLine Citation:
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PMID: 20153260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, the effects of Bacopa monnieri and its active component, bacoside A, on motor deficit and alterations of GABA receptor functional regulation in the cerebellum of epileptic rats were investigated. Scatchard analysis of [(3)H]GABA and [(3)H]bicuculline in the cerebellum of epileptic rats revealed a significant decrease in B(max) compared with control. Real-time polymerase chain reaction amplification of GABA(A) receptor subunits-GABA(Aalpha1), GABA(Aalpha5,) and GABA(Adelta)-was downregulated (P<0.001) in the cerebellum of epileptic rats compared with control rats. Epileptic rats exhibit deficits in radial arm and Y-maze performance. Treatment with B. monnieri and bacoside A reversed these changes to near-control levels. Our results suggest that changes in GABAergic activity, motor learning, and memory deficit are induced by the occurrence of repetitive seizures. Treatment with B. monnieri and bacoside A prevents the occurrence of seizures thereby reducing the impairment of GABAergic activity, motor learning, and memory deficit. |
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Authors:
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Jobin Mathew; T Peeyush Kumar; Reas S Khan; C S Paulose |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-11 |
Journal Detail:
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Title: Epilepsy & behavior : E&B Volume: 17 ISSN: 1525-5069 ISO Abbreviation: Epilepsy Behav Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: United States |
Other Details:
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Languages: eng Pagination: 441-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Biotechnology, Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Cochin University of Science and Technology, Kerala, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / therapeutic use Behavioral Symptoms* / drug therapy, etiology Bicuculline / pharmacokinetics Carbamazepine / therapeutic use Cerebellum / drug effects* Disease Models, Animal Epilepsy / chemically induced, complications*, drug therapy, pathology* GABA Antagonists / pharmacokinetics Male Maze Learning / drug effects Phytotherapy / methods* Pilocarpine Plant Preparations / therapeutic use* Protein Binding / drug effects Rats Rats, Wistar Receptors, GABA / metabolism* Saponins / therapeutic use* Triterpenes / therapeutic use* Tritium / pharmacokinetics gamma-Aminobutyric Acid / pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/GABA Antagonists; 0/Plant Preparations; 0/Receptors, GABA; 0/Saponins; 0/Triterpenes; 0/bacoside A; 10028-17-8/Tritium; 298-46-4/Carbamazepine; 485-49-4/Bicuculline; 56-12-2/gamma-Aminobutyric Acid; 92-13-7/Pilocarpine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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